A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil

Abstract Autopsy continues to play an essential role in monitoring opportunistic fungal infections. However, few studies have analysed the historical trends of fungal infections in autopsies. Here, we analyse available data on fungal infections obtained from autopsy reports during 85 years of autops...

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Autores principales:	Kátia Cristina Dantas, Thais Mauad, Carmen D. Saldiva de André, Ana Luiza Bierrenbach, Paulo Hilário Nascimento Saldiva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d4f2d84fc34143bc8fff3064668a781b
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spelling	oai:doaj.org-article:d4f2d84fc34143bc8fff3064668a781b2021-12-02T14:03:59ZA single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil10.1038/s41598-021-83587-12045-2322https://doaj.org/article/d4f2d84fc34143bc8fff3064668a781b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83587-1https://doaj.org/toc/2045-2322Abstract Autopsy continues to play an essential role in monitoring opportunistic fungal infections. However, few studies have analysed the historical trends of fungal infections in autopsies. Here, we analyse available data on fungal infections obtained from autopsy reports during 85 years of autopsies performed by the largest autopsy service in Brazil. All invasive fungal infections presented in autopsy reports between 1930 and 2015 were included. Of the 158,404 autopsy reports analysed, 1096 involved invasive fungal infections. In general, paracoccidioidomycosis (24%) was the most frequent infection, followed by candidiasis (18%), pneumocystosis (11.7%), cryptococcosis (11%), aspergillosis (11%) and histoplasmosis (3.8%). Paracoccidioidomycosis decreased after the 1950s, whereas opportunistic fungal infections increased steadily after the 1980s during the peak of the AIDS pandemic. The lung was the most frequently affected organ (73%). Disseminated infection was present in 64.5% of cases. In 26% of the 513 cases for which clinical charts were available for review, the diagnosis of opportunistic fungal infections was performed only at autopsy. Our unique 85-year history of autopsies showed a transition from endemic to opportunistic fungal infections in São Paulo, Brazil, reflecting increased urbanization, the appearance of novel diseases, such as AIDS in the 1980s, and advances in medical care over time.Kátia Cristina DantasThais MauadCarmen D. Saldiva de AndréAna Luiza BierrenbachPaulo Hilário Nascimento SaldivaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kátia Cristina Dantas Thais Mauad Carmen D. Saldiva de André Ana Luiza Bierrenbach Paulo Hilário Nascimento Saldiva A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil
description	Abstract Autopsy continues to play an essential role in monitoring opportunistic fungal infections. However, few studies have analysed the historical trends of fungal infections in autopsies. Here, we analyse available data on fungal infections obtained from autopsy reports during 85 years of autopsies performed by the largest autopsy service in Brazil. All invasive fungal infections presented in autopsy reports between 1930 and 2015 were included. Of the 158,404 autopsy reports analysed, 1096 involved invasive fungal infections. In general, paracoccidioidomycosis (24%) was the most frequent infection, followed by candidiasis (18%), pneumocystosis (11.7%), cryptococcosis (11%), aspergillosis (11%) and histoplasmosis (3.8%). Paracoccidioidomycosis decreased after the 1950s, whereas opportunistic fungal infections increased steadily after the 1980s during the peak of the AIDS pandemic. The lung was the most frequently affected organ (73%). Disseminated infection was present in 64.5% of cases. In 26% of the 513 cases for which clinical charts were available for review, the diagnosis of opportunistic fungal infections was performed only at autopsy. Our unique 85-year history of autopsies showed a transition from endemic to opportunistic fungal infections in São Paulo, Brazil, reflecting increased urbanization, the appearance of novel diseases, such as AIDS in the 1980s, and advances in medical care over time.
format	article
author	Kátia Cristina Dantas Thais Mauad Carmen D. Saldiva de André Ana Luiza Bierrenbach Paulo Hilário Nascimento Saldiva
author_facet	Kátia Cristina Dantas Thais Mauad Carmen D. Saldiva de André Ana Luiza Bierrenbach Paulo Hilário Nascimento Saldiva
author_sort	Kátia Cristina Dantas
title	A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil
title_short	A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil
title_full	A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil
title_fullStr	A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil
title_full_unstemmed	A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil
title_sort	single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in brazil
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d4f2d84fc34143bc8fff3064668a781b
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A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil

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