Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models
Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices and find normal or even accelerated glutamate cl...
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Nature Portfolio
2016
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oai:doaj.org-article:d4f6616d2af740d5b4e314bf2774e1ff2021-12-02T16:49:41ZReal-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models10.1038/ncomms112512041-1723https://doaj.org/article/d4f6616d2af740d5b4e314bf2774e1ff2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11251https://doaj.org/toc/2041-1723Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices and find normal or even accelerated glutamate clearance.Matthew P. ParsonsMatthieu P. VanniCameron L. WoodardRujun KangTimothy H. MurphyLynn A. RaymondNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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Science Q Matthew P. Parsons Matthieu P. Vanni Cameron L. Woodard Rujun Kang Timothy H. Murphy Lynn A. Raymond Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models |
description |
Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices and find normal or even accelerated glutamate clearance. |
format |
article |
author |
Matthew P. Parsons Matthieu P. Vanni Cameron L. Woodard Rujun Kang Timothy H. Murphy Lynn A. Raymond |
author_facet |
Matthew P. Parsons Matthieu P. Vanni Cameron L. Woodard Rujun Kang Timothy H. Murphy Lynn A. Raymond |
author_sort |
Matthew P. Parsons |
title |
Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models |
title_short |
Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models |
title_full |
Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models |
title_fullStr |
Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models |
title_full_unstemmed |
Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models |
title_sort |
real-time imaging of glutamate clearance reveals normal striatal uptake in huntington disease mouse models |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/d4f6616d2af740d5b4e314bf2774e1ff |
work_keys_str_mv |
AT matthewpparsons realtimeimagingofglutamateclearancerevealsnormalstriataluptakeinhuntingtondiseasemousemodels AT matthieupvanni realtimeimagingofglutamateclearancerevealsnormalstriataluptakeinhuntingtondiseasemousemodels AT cameronlwoodard realtimeimagingofglutamateclearancerevealsnormalstriataluptakeinhuntingtondiseasemousemodels AT rujunkang realtimeimagingofglutamateclearancerevealsnormalstriataluptakeinhuntingtondiseasemousemodels AT timothyhmurphy realtimeimagingofglutamateclearancerevealsnormalstriataluptakeinhuntingtondiseasemousemodels AT lynnaraymond realtimeimagingofglutamateclearancerevealsnormalstriataluptakeinhuntingtondiseasemousemodels |
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