Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models

Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices and find normal or even accelerated glutamate cl...

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Main Authors:	Matthew P. Parsons, Matthieu P. Vanni, Cameron L. Woodard, Rujun Kang, Timothy H. Murphy, Lynn A. Raymond
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/d4f6616d2af740d5b4e314bf2774e1ff
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spelling	oai:doaj.org-article:d4f6616d2af740d5b4e314bf2774e1ff2021-12-02T16:49:41ZReal-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models10.1038/ncomms112512041-1723https://doaj.org/article/d4f6616d2af740d5b4e314bf2774e1ff2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11251https://doaj.org/toc/2041-1723Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices and find normal or even accelerated glutamate clearance.Matthew P. ParsonsMatthieu P. VanniCameron L. WoodardRujun KangTimothy H. MurphyLynn A. RaymondNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew P. Parsons Matthieu P. Vanni Cameron L. Woodard Rujun Kang Timothy H. Murphy Lynn A. Raymond Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models
description	Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices and find normal or even accelerated glutamate clearance.
format	article
author	Matthew P. Parsons Matthieu P. Vanni Cameron L. Woodard Rujun Kang Timothy H. Murphy Lynn A. Raymond
author_facet	Matthew P. Parsons Matthieu P. Vanni Cameron L. Woodard Rujun Kang Timothy H. Murphy Lynn A. Raymond
author_sort	Matthew P. Parsons
title	Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models
title_short	Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models
title_full	Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models
title_fullStr	Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models
title_full_unstemmed	Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models
title_sort	real-time imaging of glutamate clearance reveals normal striatal uptake in huntington disease mouse models
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d4f6616d2af740d5b4e314bf2774e1ff
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Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models

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