DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY

An ultraviolet spectrometry method was developed for the quantitative assay of cocaine hydrochloride in a latex plastic polymer. The absorption was determined in sulfuric acid 0,5N at 233 nm, after substance extraction using the same acid. Selectivity, linearity between 4 and 20 ppm and good reprodu...

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Autores principales:	Dorelly A. BONILLA Q., Luisa F. PEÑUELA B., Noralba SIERRA M., Josías E. DÍAZ F., Jaime H. ROJAS B.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Cocaine polymer reverse high performance liquid chromatography C18 UV detection Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/d4f6e5e882e347f79bad73c9ea26154e
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spelling	oai:doaj.org-article:d4f6e5e882e347f79bad73c9ea26154e2021-11-19T04:18:41ZDEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY0121-40042145-2660https://doaj.org/article/d4f6e5e882e347f79bad73c9ea26154e2009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/772https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660An ultraviolet spectrometry method was developed for the quantitative assay of cocaine hydrochloride in a latex plastic polymer. The absorption was determined in sulfuric acid 0,5N at 233 nm, after substance extraction using the same acid. Selectivity, linearity between 4 and 20 ppm and good reproducibility were shown by this method. Detection and quantification limits were 1,6 and 4,0 ppm, respectively. Method robustness was also verified, as well as cocaine hydrochloride stability in sulfuric acid 0,5N, medium where the samples and reference standards were stored. These properties, besides its simplicity and accuracy, make it suitable for achieving proposed objectives. The validated method was applied to the determination of cocaine hydrochloride in polymer confiscated by the law Dorelly A. BONILLA Q.Luisa F. PEÑUELA B.Noralba SIERRA M.Josías E. DÍAZ F.Jaime H. ROJAS B.Universidad de AntioquiaarticleCocainepolymerreverse high performance liquid chromatographyC18UV detectionFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 15, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cocaine polymer reverse high performance liquid chromatography C18 UV detection Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Cocaine polymer reverse high performance liquid chromatography C18 UV detection Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Dorelly A. BONILLA Q. Luisa F. PEÑUELA B. Noralba SIERRA M. Josías E. DÍAZ F. Jaime H. ROJAS B. DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY
description	An ultraviolet spectrometry method was developed for the quantitative assay of cocaine hydrochloride in a latex plastic polymer. The absorption was determined in sulfuric acid 0,5N at 233 nm, after substance extraction using the same acid. Selectivity, linearity between 4 and 20 ppm and good reproducibility were shown by this method. Detection and quantification limits were 1,6 and 4,0 ppm, respectively. Method robustness was also verified, as well as cocaine hydrochloride stability in sulfuric acid 0,5N, medium where the samples and reference standards were stored. These properties, besides its simplicity and accuracy, make it suitable for achieving proposed objectives. The validated method was applied to the determination of cocaine hydrochloride in polymer confiscated by the law
format	article
author	Dorelly A. BONILLA Q. Luisa F. PEÑUELA B. Noralba SIERRA M. Josías E. DÍAZ F. Jaime H. ROJAS B.
author_facet	Dorelly A. BONILLA Q. Luisa F. PEÑUELA B. Noralba SIERRA M. Josías E. DÍAZ F. Jaime H. ROJAS B.
author_sort	Dorelly A. BONILLA Q.
title	DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY
title_short	DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY
title_full	DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY
title_fullStr	DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY
title_full_unstemmed	DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY
title_sort	development and validation of an analytical methodology for cocaine hydrochloride determination in a synthetic polymer by ultraviolet spectrometry
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/d4f6e5e882e347f79bad73c9ea26154e
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DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY

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