CYTOKINE-PRODUCING POTENTIAL OF BLOOD CELLS AND SERUM CYTOKINES IN PATIENTS WITH CHRONIC ATROPHIC GASTRITIS
Abstract. Cytokine-producing potential of peripheral blood cells was determined as a stimulation index with polyclonal activators (i.e., a cytokine production ratio of stimulated versus resting cells), as well as concentrations of cytokines were investigated in blood serum of patients with chronic a...
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| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
SPb RAACI
2014
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/d4fd449c4d214de89a5815f1625ca187 |
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| Sumario: | Abstract. Cytokine-producing potential of peripheral blood cells was determined as a stimulation index with polyclonal activators (i.e., a cytokine production ratio of stimulated versus resting cells), as well as concentrations of cytokines were investigated in blood serum of patients with chronic atrophic gastritis. It was revealed that the stimulation indices concerning production of TNFα, IL-1β, IL-6, IL-8 and IL-10 by whole blood cells, along with serum concentrations of IL-8 and IL-18BP were increased in patients with epithelial dysplasia of stomach mucosa, as compared to patients without dysplasia. It was sahown, that the patients with higher polyclonal stimulation indices for IL-6 and IL-8 (resp., > 164 and > 38 arbitrary units) should be referred to a high-risk group for development of mucous epithelial dysplasia of stomach. |
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