Evaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses

Brett E Thomes, Thomas A Callaghan Alcon Research Ltd (A Novartis Company), Fort Worth, TX, USA Purpose: To evaluate the impact of continuous manufacturing process improvements on glistening formation in AcrySof hydrophobic acrylic intraocular lenses (IOLs) by comparing lenses manufactured in 2003 w...

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Autores principales:	Thomes BE, Callaghan TA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d4fd5a005cfa4ee38c64df96133018db
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spelling	oai:doaj.org-article:d4fd5a005cfa4ee38c64df96133018db2021-12-02T00:59:31ZEvaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses1177-54671177-5483https://doaj.org/article/d4fd5a005cfa4ee38c64df96133018db2013-07-01T00:00:00Zhttp://www.dovepress.com/evaluation-of-in-vitro-glistening-formation-in-hydrophobic-acrylic-int-a13801https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Brett E Thomes, Thomas A Callaghan Alcon Research Ltd (A Novartis Company), Fort Worth, TX, USA Purpose: To evaluate the impact of continuous manufacturing process improvements on glistening formation in AcrySof hydrophobic acrylic intraocular lenses (IOLs) by comparing lenses manufactured in 2003 with lenses manufactured in 2012. Methods: Glistenings were experimentally created as aqueous-filled microvacuoles utilizing an accelerated laboratory method by immersing the lens in water at 45°C for 24 hours and then reducing the temperature to 37°C for 2.5 hours. To determine the impact of continuous improvements on glistening formation, AcrySof IOLs (Alcon Laboratories, Inc) Model SB30 AL manufactured in 2003 were compared with AcrySof IOLs Model SN60 WF manufactured in 2012. Results: Glistenings were present in all lenses after the accelerated microvacuole test method. The mean microvacuole density for IOLs manufactured in 2003 was 315.7 microvacuoles per square millimeter (MVs/mm2) with a glistening severity less than 100 MVs/mm2 in 1.0% of the IOLs. The mean microvacuole density for IOLs manufactured in 2012 was 39.9 MVs/mm2 with a glistening severity less than 100 MVs/mm2 in 95.2% of the IOLs. Laboratory-induced microvacuole density was significantly lower in IOLs manufactured in 2012 (mean 39.9 MVs/mm2) relative to IOLs manufactured in 2003 (mean 315.7 MVs/mm2) as indicated by the Wilcoxon test of significance (P < 0.0005). Conclusion: AcrySof IOLs recently manufactured in 2012 demonstrated a significant reduction in glistening density (87% reduction in mean density) as a result of continuous manufacturing process improvements compared with IOLs manufactured in 2003. Keywords: microvacuoles, glistenings, AcrySof, intraocular lensesThomes BECallaghan TADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1529-1534 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Thomes BE Callaghan TA Evaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses
description	Brett E Thomes, Thomas A Callaghan Alcon Research Ltd (A Novartis Company), Fort Worth, TX, USA Purpose: To evaluate the impact of continuous manufacturing process improvements on glistening formation in AcrySof hydrophobic acrylic intraocular lenses (IOLs) by comparing lenses manufactured in 2003 with lenses manufactured in 2012. Methods: Glistenings were experimentally created as aqueous-filled microvacuoles utilizing an accelerated laboratory method by immersing the lens in water at 45°C for 24 hours and then reducing the temperature to 37°C for 2.5 hours. To determine the impact of continuous improvements on glistening formation, AcrySof IOLs (Alcon Laboratories, Inc) Model SB30 AL manufactured in 2003 were compared with AcrySof IOLs Model SN60 WF manufactured in 2012. Results: Glistenings were present in all lenses after the accelerated microvacuole test method. The mean microvacuole density for IOLs manufactured in 2003 was 315.7 microvacuoles per square millimeter (MVs/mm2) with a glistening severity less than 100 MVs/mm2 in 1.0% of the IOLs. The mean microvacuole density for IOLs manufactured in 2012 was 39.9 MVs/mm2 with a glistening severity less than 100 MVs/mm2 in 95.2% of the IOLs. Laboratory-induced microvacuole density was significantly lower in IOLs manufactured in 2012 (mean 39.9 MVs/mm2) relative to IOLs manufactured in 2003 (mean 315.7 MVs/mm2) as indicated by the Wilcoxon test of significance (P < 0.0005). Conclusion: AcrySof IOLs recently manufactured in 2012 demonstrated a significant reduction in glistening density (87% reduction in mean density) as a result of continuous manufacturing process improvements compared with IOLs manufactured in 2003. Keywords: microvacuoles, glistenings, AcrySof, intraocular lenses
format	article
author	Thomes BE Callaghan TA
author_facet	Thomes BE Callaghan TA
author_sort	Thomes BE
title	Evaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses
title_short	Evaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses
title_full	Evaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses
title_fullStr	Evaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses
title_full_unstemmed	Evaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses
title_sort	evaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/d4fd5a005cfa4ee38c64df96133018db
work_keys_str_mv	AT thomesbe evaluationofinvitroglisteningformationinhydrophobicacrylicintraocularlenses AT callaghanta evaluationofinvitroglisteningformationinhydrophobicacrylicintraocularlenses
_version_	1718403408778493952

Evaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses

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