Reduced brain resting-state network specificity in infants compared with adults

Korey P Wylie,1,* Donald C Rojas,1,* Randal G Ross,1 Sharon K Hunter,1 Keeran Maharajh,1 Marc-Andre Cornier,2 Jason R Tregellas1,3 1Department of Psychiatry, 2Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA...

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Autores principales:	Wylie KP, Rojas DC, Ross RG, Hunter SK, Maharajh K, Cornier M-A, Tregellas JR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d4fe83ee771a4388847c46d1a7376a16
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spelling	oai:doaj.org-article:d4fe83ee771a4388847c46d1a7376a162021-12-02T06:18:00ZReduced brain resting-state network specificity in infants compared with adults1178-2021https://doaj.org/article/d4fe83ee771a4388847c46d1a7376a162014-07-01T00:00:00Zhttp://www.dovepress.com/reduced-brain-resting-state-network-specificity-in-infants-compared-wi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Korey P Wylie,1,* Donald C Rojas,1,* Randal G Ross,1 Sharon K Hunter,1 Keeran Maharajh,1 Marc-Andre Cornier,2 Jason R Tregellas1,3 1Department of Psychiatry, 2Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; 3Denver Veterans Affairs Medical Center, Denver, CO, USA *These authors contributed equally to this work Purpose: Infant resting-state networks do not exhibit the same connectivity patterns as those of young children and adults. Current theories of brain development emphasize developmental progression in regional and network specialization. We compared infant and adult functional connectivity, predicting that infants would exhibit less regional specificity and greater internetwork communication compared with adults.Patients and methods: Functional magnetic resonance imaging at rest was acquired in 12 healthy, term infants and 17 adults. Resting-state networks were extracted, using independent components analysis, and the resulting components were then compared between the adult and infant groups.Results: Adults exhibited stronger connectivity in the posterior cingulate cortex node of the default mode network, but infants had higher connectivity in medial prefrontal cortex/anterior cingulate cortex than adults. Adult connectivity was typically higher than infant connectivity within structures previously associated with the various networks, whereas infant connectivity was frequently higher outside of these structures. Internetwork communication was significantly higher in infants than in adults.Conclusion: We interpret these findings as consistent with evidence suggesting that resting-state network development is associated with increasing spatial specificity, possibly reflecting the corresponding functional specialization of regions and their interconnections through experience. Keywords: functional connectivity magnetic resonance imaging, networks, development, infancy, resting-state, connectivityWylie KPRojas DCRoss RGHunter SKMaharajh KCornier M-ATregellas JRDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1349-1359 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wylie KP Rojas DC Ross RG Hunter SK Maharajh K Cornier M-A Tregellas JR Reduced brain resting-state network specificity in infants compared with adults
description	Korey P Wylie,1,* Donald C Rojas,1,* Randal G Ross,1 Sharon K Hunter,1 Keeran Maharajh,1 Marc-Andre Cornier,2 Jason R Tregellas1,3 1Department of Psychiatry, 2Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; 3Denver Veterans Affairs Medical Center, Denver, CO, USA *These authors contributed equally to this work Purpose: Infant resting-state networks do not exhibit the same connectivity patterns as those of young children and adults. Current theories of brain development emphasize developmental progression in regional and network specialization. We compared infant and adult functional connectivity, predicting that infants would exhibit less regional specificity and greater internetwork communication compared with adults.Patients and methods: Functional magnetic resonance imaging at rest was acquired in 12 healthy, term infants and 17 adults. Resting-state networks were extracted, using independent components analysis, and the resulting components were then compared between the adult and infant groups.Results: Adults exhibited stronger connectivity in the posterior cingulate cortex node of the default mode network, but infants had higher connectivity in medial prefrontal cortex/anterior cingulate cortex than adults. Adult connectivity was typically higher than infant connectivity within structures previously associated with the various networks, whereas infant connectivity was frequently higher outside of these structures. Internetwork communication was significantly higher in infants than in adults.Conclusion: We interpret these findings as consistent with evidence suggesting that resting-state network development is associated with increasing spatial specificity, possibly reflecting the corresponding functional specialization of regions and their interconnections through experience. Keywords: functional connectivity magnetic resonance imaging, networks, development, infancy, resting-state, connectivity
format	article
author	Wylie KP Rojas DC Ross RG Hunter SK Maharajh K Cornier M-A Tregellas JR
author_facet	Wylie KP Rojas DC Ross RG Hunter SK Maharajh K Cornier M-A Tregellas JR
author_sort	Wylie KP
title	Reduced brain resting-state network specificity in infants compared with adults
title_short	Reduced brain resting-state network specificity in infants compared with adults
title_full	Reduced brain resting-state network specificity in infants compared with adults
title_fullStr	Reduced brain resting-state network specificity in infants compared with adults
title_full_unstemmed	Reduced brain resting-state network specificity in infants compared with adults
title_sort	reduced brain resting-state network specificity in infants compared with adults
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/d4fe83ee771a4388847c46d1a7376a16
work_keys_str_mv	AT wyliekp reducedbrainrestingstatenetworkspecificityininfantscomparedwithadults AT rojasdc reducedbrainrestingstatenetworkspecificityininfantscomparedwithadults AT rossrg reducedbrainrestingstatenetworkspecificityininfantscomparedwithadults AT huntersk reducedbrainrestingstatenetworkspecificityininfantscomparedwithadults AT maharajhk reducedbrainrestingstatenetworkspecificityininfantscomparedwithadults AT cornierma reducedbrainrestingstatenetworkspecificityininfantscomparedwithadults AT tregellasjr reducedbrainrestingstatenetworkspecificityininfantscomparedwithadults
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Reduced brain resting-state network specificity in infants compared with adults

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