Anti-Platelet Fraction Isolated from Galega Officinalis
A fraction from crude extract of Galega officinalis has been purified by column chromatography on Sephadex G-25, Sepharose 4B, DEAE-Cellulose and Sephadex G-100. The final purification factor of the fraction is 120. The peak in elution profile after Sephadex G-150 shows a molecular weight of 100-140...
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Sciendo
2016
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oai:doaj.org-article:d50496822f2a4cf3b1bc83a9cbc624f12021-12-02T16:42:08ZAnti-Platelet Fraction Isolated from Galega Officinalis0324-175010.1515/amb-2016-0011https://doaj.org/article/d50496822f2a4cf3b1bc83a9cbc624f12016-10-01T00:00:00Zhttps://doi.org/10.1515/amb-2016-0011https://doaj.org/toc/0324-1750A fraction from crude extract of Galega officinalis has been purified by column chromatography on Sephadex G-25, Sepharose 4B, DEAE-Cellulose and Sephadex G-100. The final purification factor of the fraction is 120. The peak in elution profile after Sephadex G-150 shows a molecular weight of 100-140 kDa. The isolated fraction appears to have 74% polysaccharides and 23% of proteins. No loss of activity of the final fraction is observed after storage for several months at 4°C and in lyophilized condition. The fraction compounds inhibit platelet aggregation induced by ADP, collagen and thrombin.Atanasov A.Sciendoarticlegalega officinalisantiplatelet fractionMedicineRENActa Medica Bulgarica, Vol 43, Iss 2, Pp 5-10 (2016) |
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DOAJ |
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EN |
| topic |
galega officinalis antiplatelet fraction Medicine R |
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galega officinalis antiplatelet fraction Medicine R Atanasov A. Anti-Platelet Fraction Isolated from Galega Officinalis |
| description |
A fraction from crude extract of Galega officinalis has been purified by column chromatography on Sephadex G-25, Sepharose 4B, DEAE-Cellulose and Sephadex G-100. The final purification factor of the fraction is 120. The peak in elution profile after Sephadex G-150 shows a molecular weight of 100-140 kDa. The isolated fraction appears to have 74% polysaccharides and 23% of proteins. No loss of activity of the final fraction is observed after storage for several months at 4°C and in lyophilized condition. The fraction compounds inhibit platelet aggregation induced by ADP, collagen and thrombin. |
| format |
article |
| author |
Atanasov A. |
| author_facet |
Atanasov A. |
| author_sort |
Atanasov A. |
| title |
Anti-Platelet Fraction Isolated from Galega Officinalis |
| title_short |
Anti-Platelet Fraction Isolated from Galega Officinalis |
| title_full |
Anti-Platelet Fraction Isolated from Galega Officinalis |
| title_fullStr |
Anti-Platelet Fraction Isolated from Galega Officinalis |
| title_full_unstemmed |
Anti-Platelet Fraction Isolated from Galega Officinalis |
| title_sort |
anti-platelet fraction isolated from galega officinalis |
| publisher |
Sciendo |
| publishDate |
2016 |
| url |
https://doaj.org/article/d50496822f2a4cf3b1bc83a9cbc624f1 |
| work_keys_str_mv |
AT atanasova antiplateletfractionisolatedfromgalegaofficinalis |
| _version_ |
1718383602625937408 |