Anti-Platelet Fraction Isolated from Galega Officinalis

A fraction from crude extract of Galega officinalis has been purified by column chromatography on Sephadex G-25, Sepharose 4B, DEAE-Cellulose and Sephadex G-100. The final purification factor of the fraction is 120. The peak in elution profile after Sephadex G-150 shows a molecular weight of 100-140...

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Main Author:	Atanasov A.
Format:	article
Language:	EN
Published:	Sciendo 2016
Subjects:	galega officinalis antiplatelet fraction Medicine R
Online Access:	https://doaj.org/article/d50496822f2a4cf3b1bc83a9cbc624f1
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spelling	oai:doaj.org-article:d50496822f2a4cf3b1bc83a9cbc624f12021-12-02T16:42:08ZAnti-Platelet Fraction Isolated from Galega Officinalis0324-175010.1515/amb-2016-0011https://doaj.org/article/d50496822f2a4cf3b1bc83a9cbc624f12016-10-01T00:00:00Zhttps://doi.org/10.1515/amb-2016-0011https://doaj.org/toc/0324-1750A fraction from crude extract of Galega officinalis has been purified by column chromatography on Sephadex G-25, Sepharose 4B, DEAE-Cellulose and Sephadex G-100. The final purification factor of the fraction is 120. The peak in elution profile after Sephadex G-150 shows a molecular weight of 100-140 kDa. The isolated fraction appears to have 74% polysaccharides and 23% of proteins. No loss of activity of the final fraction is observed after storage for several months at 4°C and in lyophilized condition. The fraction compounds inhibit platelet aggregation induced by ADP, collagen and thrombin.Atanasov A.Sciendoarticlegalega officinalisantiplatelet fractionMedicineRENActa Medica Bulgarica, Vol 43, Iss 2, Pp 5-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	galega officinalis antiplatelet fraction Medicine R
spellingShingle	galega officinalis antiplatelet fraction Medicine R Atanasov A. Anti-Platelet Fraction Isolated from Galega Officinalis
description	A fraction from crude extract of Galega officinalis has been purified by column chromatography on Sephadex G-25, Sepharose 4B, DEAE-Cellulose and Sephadex G-100. The final purification factor of the fraction is 120. The peak in elution profile after Sephadex G-150 shows a molecular weight of 100-140 kDa. The isolated fraction appears to have 74% polysaccharides and 23% of proteins. No loss of activity of the final fraction is observed after storage for several months at 4°C and in lyophilized condition. The fraction compounds inhibit platelet aggregation induced by ADP, collagen and thrombin.
format	article
author	Atanasov A.
author_facet	Atanasov A.
author_sort	Atanasov A.
title	Anti-Platelet Fraction Isolated from Galega Officinalis
title_short	Anti-Platelet Fraction Isolated from Galega Officinalis
title_full	Anti-Platelet Fraction Isolated from Galega Officinalis
title_fullStr	Anti-Platelet Fraction Isolated from Galega Officinalis
title_full_unstemmed	Anti-Platelet Fraction Isolated from Galega Officinalis
title_sort	anti-platelet fraction isolated from galega officinalis
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/d50496822f2a4cf3b1bc83a9cbc624f1
work_keys_str_mv	AT atanasova antiplateletfractionisolatedfromgalegaofficinalis
_version_	1718383602625937408

Anti-Platelet Fraction Isolated from Galega Officinalis

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