A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

Neutralizing nanobodies (Nb) are of considerable interest as therapeutic agents for COVID-19 treatment. Here, the authors functionally and structurally characterize Nbs that bind with high affinity to the receptor binding domain of the SARS-CoV-2 spike protein and show that an engineered homotrimeri...

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Autores principales:	Jiandong Huo, Halina Mikolajek, Audrey Le Bas, Jordan J. Clark, Parul Sharma, Anja Kipar, Joshua Dormon, Chelsea Norman, Miriam Weckener, Daniel K. Clare, Peter J. Harrison, Julia A. Tree, Karen R. Buttigieg, Francisco J. Salguero, Robert Watson, Daniel Knott, Oliver Carnell, Didier Ngabo, Michael J. Elmore, Susan Fotheringham, Adam Harding, Lucile Moynié, Philip N. Ward, Maud Dumoux, Tessa Prince, Yper Hall, Julian A. Hiscox, Andrew Owen, William James, Miles W. Carroll, James P. Stewart, James H. Naismith, Raymond J. Owens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d505e344aed84336a3d7f7d369c5238a
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spelling	oai:doaj.org-article:d505e344aed84336a3d7f7d369c5238a2021-12-02T17:27:04ZA potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-1910.1038/s41467-021-25480-z2041-1723https://doaj.org/article/d505e344aed84336a3d7f7d369c5238a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25480-zhttps://doaj.org/toc/2041-1723Neutralizing nanobodies (Nb) are of considerable interest as therapeutic agents for COVID-19 treatment. Here, the authors functionally and structurally characterize Nbs that bind with high affinity to the receptor binding domain of the SARS-CoV-2 spike protein and show that an engineered homotrimeric Nb prevents disease progression in a Syrian hamster model of COVID-19 when administered intranasally.Jiandong HuoHalina MikolajekAudrey Le BasJordan J. ClarkParul SharmaAnja KiparJoshua DormonChelsea NormanMiriam WeckenerDaniel K. ClarePeter J. HarrisonJulia A. TreeKaren R. ButtigiegFrancisco J. SalgueroRobert WatsonDaniel KnottOliver CarnellDidier NgaboMichael J. ElmoreSusan FotheringhamAdam HardingLucile MoyniéPhilip N. WardMaud DumouxTessa PrinceYper HallJulian A. HiscoxAndrew OwenWilliam JamesMiles W. CarrollJames P. StewartJames H. NaismithRaymond J. OwensNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiandong Huo Halina Mikolajek Audrey Le Bas Jordan J. Clark Parul Sharma Anja Kipar Joshua Dormon Chelsea Norman Miriam Weckener Daniel K. Clare Peter J. Harrison Julia A. Tree Karen R. Buttigieg Francisco J. Salguero Robert Watson Daniel Knott Oliver Carnell Didier Ngabo Michael J. Elmore Susan Fotheringham Adam Harding Lucile Moynié Philip N. Ward Maud Dumoux Tessa Prince Yper Hall Julian A. Hiscox Andrew Owen William James Miles W. Carroll James P. Stewart James H. Naismith Raymond J. Owens A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
description	Neutralizing nanobodies (Nb) are of considerable interest as therapeutic agents for COVID-19 treatment. Here, the authors functionally and structurally characterize Nbs that bind with high affinity to the receptor binding domain of the SARS-CoV-2 spike protein and show that an engineered homotrimeric Nb prevents disease progression in a Syrian hamster model of COVID-19 when administered intranasally.
format	article
author	Jiandong Huo Halina Mikolajek Audrey Le Bas Jordan J. Clark Parul Sharma Anja Kipar Joshua Dormon Chelsea Norman Miriam Weckener Daniel K. Clare Peter J. Harrison Julia A. Tree Karen R. Buttigieg Francisco J. Salguero Robert Watson Daniel Knott Oliver Carnell Didier Ngabo Michael J. Elmore Susan Fotheringham Adam Harding Lucile Moynié Philip N. Ward Maud Dumoux Tessa Prince Yper Hall Julian A. Hiscox Andrew Owen William James Miles W. Carroll James P. Stewart James H. Naismith Raymond J. Owens
author_facet	Jiandong Huo Halina Mikolajek Audrey Le Bas Jordan J. Clark Parul Sharma Anja Kipar Joshua Dormon Chelsea Norman Miriam Weckener Daniel K. Clare Peter J. Harrison Julia A. Tree Karen R. Buttigieg Francisco J. Salguero Robert Watson Daniel Knott Oliver Carnell Didier Ngabo Michael J. Elmore Susan Fotheringham Adam Harding Lucile Moynié Philip N. Ward Maud Dumoux Tessa Prince Yper Hall Julian A. Hiscox Andrew Owen William James Miles W. Carroll James P. Stewart James H. Naismith Raymond J. Owens
author_sort	Jiandong Huo
title	A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
title_short	A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
title_full	A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
title_fullStr	A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
title_full_unstemmed	A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
title_sort	potent sars-cov-2 neutralising nanobody shows therapeutic efficacy in the syrian golden hamster model of covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d505e344aed84336a3d7f7d369c5238a
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A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

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