Staphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages

Plain language summary Persons who inject drugs are at increased risk of developing a bloodstream infection caused by the bacterium Staphylococcus aureus. To investigate whether this risk is due to transmission of the bacterium within this community, we compared the complete set of genes (genome) of...

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Autores principales:	Laura R. Marks, Juan J. Calix, John A. Wildenthal, Meghan A. Wallace, Sanjam S. Sawhney, Eric M. Ransom, Michael J. Durkin, Jeffrey P. Henderson, Carey-Ann D. Burnham, Gautam Dantas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/d509b01986534a99aa8059e3311d7e37
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spelling	oai:doaj.org-article:d509b01986534a99aa8059e3311d7e372021-12-05T12:11:09ZStaphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages10.1038/s43856-021-00053-92730-664Xhttps://doaj.org/article/d509b01986534a99aa8059e3311d7e372021-11-01T00:00:00Zhttps://doi.org/10.1038/s43856-021-00053-9https://doaj.org/toc/2730-664XPlain language summary Persons who inject drugs are at increased risk of developing a bloodstream infection caused by the bacterium Staphylococcus aureus. To investigate whether this risk is due to transmission of the bacterium within this community, we compared the complete set of genes (genome) of S. aureus isolated from people with bloodstream infections who do and do not inject drugs. S. aureus causing bloodstream infections in persons who inject drugs were much more likely to belong to one of multiple networks of very closely related subtypes, demonstrating that in some communities the bacteria causing this type of infection can likely be directly transmitted from person to person through high-risk injection drug use practices, such as sharing needles. Therefore, invasive infections in persons who inject drugs can spread like communicable diseases and this can inform future policy on how to prevent them.Laura R. MarksJuan J. CalixJohn A. WildenthalMeghan A. WallaceSanjam S. SawhneyEric M. RansomMichael J. DurkinJeffrey P. HendersonCarey-Ann D. BurnhamGautam DantasNature PortfolioarticleMedicineRENCommunications Medicine, Vol 1, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Laura R. Marks Juan J. Calix John A. Wildenthal Meghan A. Wallace Sanjam S. Sawhney Eric M. Ransom Michael J. Durkin Jeffrey P. Henderson Carey-Ann D. Burnham Gautam Dantas Staphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages
description	Plain language summary Persons who inject drugs are at increased risk of developing a bloodstream infection caused by the bacterium Staphylococcus aureus. To investigate whether this risk is due to transmission of the bacterium within this community, we compared the complete set of genes (genome) of S. aureus isolated from people with bloodstream infections who do and do not inject drugs. S. aureus causing bloodstream infections in persons who inject drugs were much more likely to belong to one of multiple networks of very closely related subtypes, demonstrating that in some communities the bacteria causing this type of infection can likely be directly transmitted from person to person through high-risk injection drug use practices, such as sharing needles. Therefore, invasive infections in persons who inject drugs can spread like communicable diseases and this can inform future policy on how to prevent them.
format	article
author	Laura R. Marks Juan J. Calix John A. Wildenthal Meghan A. Wallace Sanjam S. Sawhney Eric M. Ransom Michael J. Durkin Jeffrey P. Henderson Carey-Ann D. Burnham Gautam Dantas
author_facet	Laura R. Marks Juan J. Calix John A. Wildenthal Meghan A. Wallace Sanjam S. Sawhney Eric M. Ransom Michael J. Durkin Jeffrey P. Henderson Carey-Ann D. Burnham Gautam Dantas
author_sort	Laura R. Marks
title	Staphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages
title_short	Staphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages
title_full	Staphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages
title_fullStr	Staphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages
title_full_unstemmed	Staphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages
title_sort	staphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d509b01986534a99aa8059e3311d7e37
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Staphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages

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