Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency

Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency

The pathways involved in exit from pluripotency in human embryonic stem cells are poorly understood. Here, the authors performed a CRISPR-based screen to identify genes that promote exit from naïve pluripotency and find a role for folliculin (FLCN) by regulating the mTOR and Wnt pathways.

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Autores principales: J. Mathieu, D. Detraux, D. Kuppers, Y. Wang, C. Cavanaugh, S. Sidhu, S. Levy, A. M. Robitaille, A. Ferreccio, T. Bottorff, A. McAlister, L. Somasundaram, F. Artoni, S. Battle, R. D. Hawkins, R. T. Moon, C. B. Ware, P. J. Paddison, H. Ruohola-Baker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d50b9ac4e8764f89b3e5badb92229b82
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spelling oai:doaj.org-article:d50b9ac4e8764f89b3e5badb92229b822021-12-02T14:39:19ZFolliculin regulates mTORC1/2 and WNT pathways in early human pluripotency10.1038/s41467-018-08020-02041-1723https://doaj.org/article/d50b9ac4e8764f89b3e5badb92229b822019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08020-0https://doaj.org/toc/2041-1723The pathways involved in exit from pluripotency in human embryonic stem cells are poorly understood. Here, the authors performed a CRISPR-based screen to identify genes that promote exit from naïve pluripotency and find a role for folliculin (FLCN) by regulating the mTOR and Wnt pathways.J. MathieuD. DetrauxD. KuppersY. WangC. CavanaughS. SidhuS. LevyA. M. RobitailleA. FerreccioT. BottorffA. McAlisterL. SomasundaramF. ArtoniS. BattleR. D. HawkinsR. T. MoonC. B. WareP. J. PaddisonH. Ruohola-BakerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
J. Mathieu
D. Detraux
D. Kuppers
Y. Wang
C. Cavanaugh
S. Sidhu
S. Levy
A. M. Robitaille
A. Ferreccio
T. Bottorff
A. McAlister
L. Somasundaram
F. Artoni
S. Battle
R. D. Hawkins
R. T. Moon
C. B. Ware
P. J. Paddison
H. Ruohola-Baker
Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
description The pathways involved in exit from pluripotency in human embryonic stem cells are poorly understood. Here, the authors performed a CRISPR-based screen to identify genes that promote exit from naïve pluripotency and find a role for folliculin (FLCN) by regulating the mTOR and Wnt pathways.
format article
author J. Mathieu
D. Detraux
D. Kuppers
Y. Wang
C. Cavanaugh
S. Sidhu
S. Levy
A. M. Robitaille
A. Ferreccio
T. Bottorff
A. McAlister
L. Somasundaram
F. Artoni
S. Battle
R. D. Hawkins
R. T. Moon
C. B. Ware
P. J. Paddison
H. Ruohola-Baker
author_facet J. Mathieu
D. Detraux
D. Kuppers
Y. Wang
C. Cavanaugh
S. Sidhu
S. Levy
A. M. Robitaille
A. Ferreccio
T. Bottorff
A. McAlister
L. Somasundaram
F. Artoni
S. Battle
R. D. Hawkins
R. T. Moon
C. B. Ware
P. J. Paddison
H. Ruohola-Baker
author_sort J. Mathieu
title Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
title_short Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
title_full Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
title_fullStr Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
title_full_unstemmed Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
title_sort folliculin regulates mtorc1/2 and wnt pathways in early human pluripotency
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/d50b9ac4e8764f89b3e5badb92229b82
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