Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair

The conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM structure of the yeast TFIIH/Rad4–Rad23-Rad33 complex b...

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Autores principales:	Trevor van Eeuwen, Yoonjung Shim, Hee Jong Kim, Tingting Zhao, Shrabani Basu, Benjamin A. Garcia, Craig D. Kaplan, Jung-Hyun Min, Kenji Murakami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d50d4da2dfcb426987c2cc95413c64ea
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spelling	oai:doaj.org-article:d50d4da2dfcb426987c2cc95413c64ea2021-12-02T17:52:38ZCryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair10.1038/s41467-021-23684-x2041-1723https://doaj.org/article/d50d4da2dfcb426987c2cc95413c64ea2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23684-xhttps://doaj.org/toc/2041-1723The conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM structure of the yeast TFIIH/Rad4–Rad23-Rad33 complex bound to a DNA containing a single carcinogen-DNA adduct.Trevor van EeuwenYoonjung ShimHee Jong KimTingting ZhaoShrabani BasuBenjamin A. GarciaCraig D. KaplanJung-Hyun MinKenji MurakamiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Trevor van Eeuwen Yoonjung Shim Hee Jong Kim Tingting Zhao Shrabani Basu Benjamin A. Garcia Craig D. Kaplan Jung-Hyun Min Kenji Murakami Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair
description	The conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM structure of the yeast TFIIH/Rad4–Rad23-Rad33 complex bound to a DNA containing a single carcinogen-DNA adduct.
format	article
author	Trevor van Eeuwen Yoonjung Shim Hee Jong Kim Tingting Zhao Shrabani Basu Benjamin A. Garcia Craig D. Kaplan Jung-Hyun Min Kenji Murakami
author_facet	Trevor van Eeuwen Yoonjung Shim Hee Jong Kim Tingting Zhao Shrabani Basu Benjamin A. Garcia Craig D. Kaplan Jung-Hyun Min Kenji Murakami
author_sort	Trevor van Eeuwen
title	Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair
title_short	Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair
title_full	Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair
title_fullStr	Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair
title_full_unstemmed	Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair
title_sort	cryo-em structure of tfiih/rad4–rad23–rad33 in damaged dna opening in nucleotide excision repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d50d4da2dfcb426987c2cc95413c64ea
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Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair

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