A Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels

Background: Household air pollution (HAP)-associated acute <a title="Learn more about Lower respiratory tract infection" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/lower-respiratory-tract-infection">lower respiratory infections</a> cause 455,000...

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Autores principales:	Alison Lee, Patrick Kinney, Steve Chillrud, Darby Jack
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2015
Materias:	biomass household air pollution indoor air pollution innate immunity long-term exposure PM2.5 Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/d50da1c5f14d4b7493be502c20fedc6e
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spelling	oai:doaj.org-article:d50da1c5f14d4b7493be502c20fedc6e2021-12-02T11:33:14ZA Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels2214-999610.1016/j.aogh.2015.08.006https://doaj.org/article/d50da1c5f14d4b7493be502c20fedc6e2015-11-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/1509https://doaj.org/toc/2214-9996Background: Household air pollution (HAP)-associated acute <a title="Learn more about Lower respiratory tract infection" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/lower-respiratory-tract-infection">lower respiratory infections</a> cause 455,000 deaths and a loss of 39.1 million disability-adjusted life years annually. The immunomodulatory mechanisms of HAP are poorly understood. Objectives: The aim of this study was to conduct a systematic review of all studies examining the mechanisms underlying the relationship between HAP secondary to solid fuel exposure and acute lower respiratory tract infection to evaluate current available evidence, identify gaps in knowledge, and propose future research priorities. Methods: We conducted and report on studies in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. In all, 133 articles were fully reviewed and main characteristics were detailed, namely study design and outcome, including <a title="Learn more about In vivo" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/in-vivo">in vivo</a> versus <a title="Learn more about In vitro" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/in-vitro">in vitro</a> and pollutants analyzed. Thirty-six studies were included in a nonexhaustive review of the <a title="Learn more about Innate Immune System" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/innate-immune-system">innate immune system</a> effects of ambient air pollution, traffic-related air pollution, or wood smoke exposure of developed country origin. Seventeen studies investigated the effects of HAP-associated solid fuel (biomass or coal smoke) exposure on <a title="Learn more about Airway Inflammation" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/airway-inflammation">airway inflammation</a> and innate immune system function. Results: Particulate matter may modulate the innate immune system and increase susceptibility to infection through a) alveolar macrophage-driven inflammation, recruitment of <a title="Learn more about Neutrophil" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/neutrophil">neutrophils</a>, and disruption of barrier defenses; b) alterations in <a title="Learn more about Alveolar Macrophage" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/alveolar-macrophage">alveolar macrophage</a> phagocytosis and intracellular killing; and c) increased susceptibility to infection via upregulation of receptors involved in pathogen invasion. Conclusions: HAP secondary to the burning of biomass fuels alters <a title="Learn more about Innate Immunity" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/innate-immunity">innate immunity</a>, predisposing children to acute lower respiratory tract infections. Data from biomass exposure in developing countries are scarce. Further study is needed to define the inflammatory response, alterations in phagocytic function, and upregulation of receptors important in bacterial and viral binding. These studies have important public health implications and may lead to the design of interventions to improve the health of billions of people daily.Alison LeePatrick KinneySteve ChillrudDarby JackUbiquity Pressarticlebiomasshousehold air pollutionindoor air pollutioninnate immunitylong-term exposurePM2.5Infectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 81, Iss 3, Pp 368-374 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomass household air pollution indoor air pollution innate immunity long-term exposure PM2.5 Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	biomass household air pollution indoor air pollution innate immunity long-term exposure PM2.5 Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Alison Lee Patrick Kinney Steve Chillrud Darby Jack A Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels
description	Background: Household air pollution (HAP)-associated acute <a title="Learn more about Lower respiratory tract infection" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/lower-respiratory-tract-infection">lower respiratory infections</a> cause 455,000 deaths and a loss of 39.1 million disability-adjusted life years annually. The immunomodulatory mechanisms of HAP are poorly understood. Objectives: The aim of this study was to conduct a systematic review of all studies examining the mechanisms underlying the relationship between HAP secondary to solid fuel exposure and acute lower respiratory tract infection to evaluate current available evidence, identify gaps in knowledge, and propose future research priorities. Methods: We conducted and report on studies in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. In all, 133 articles were fully reviewed and main characteristics were detailed, namely study design and outcome, including <a title="Learn more about In vivo" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/in-vivo">in vivo</a> versus <a title="Learn more about In vitro" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/in-vitro">in vitro</a> and pollutants analyzed. Thirty-six studies were included in a nonexhaustive review of the <a title="Learn more about Innate Immune System" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/innate-immune-system">innate immune system</a> effects of ambient air pollution, traffic-related air pollution, or wood smoke exposure of developed country origin. Seventeen studies investigated the effects of HAP-associated solid fuel (biomass or coal smoke) exposure on <a title="Learn more about Airway Inflammation" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/airway-inflammation">airway inflammation</a> and innate immune system function. Results: Particulate matter may modulate the innate immune system and increase susceptibility to infection through a) alveolar macrophage-driven inflammation, recruitment of <a title="Learn more about Neutrophil" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/neutrophil">neutrophils</a>, and disruption of barrier defenses; b) alterations in <a title="Learn more about Alveolar Macrophage" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/alveolar-macrophage">alveolar macrophage</a> phagocytosis and intracellular killing; and c) increased susceptibility to infection via upregulation of receptors involved in pathogen invasion. Conclusions: HAP secondary to the burning of biomass fuels alters <a title="Learn more about Innate Immunity" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/innate-immunity">innate immunity</a>, predisposing children to acute lower respiratory tract infections. Data from biomass exposure in developing countries are scarce. Further study is needed to define the inflammatory response, alterations in phagocytic function, and upregulation of receptors important in bacterial and viral binding. These studies have important public health implications and may lead to the design of interventions to improve the health of billions of people daily.
format	article
author	Alison Lee Patrick Kinney Steve Chillrud Darby Jack
author_facet	Alison Lee Patrick Kinney Steve Chillrud Darby Jack
author_sort	Alison Lee
title	A Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels
title_short	A Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels
title_full	A Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels
title_fullStr	A Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels
title_full_unstemmed	A Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels
title_sort	systematic review of innate immunomodulatory effects of household air pollution secondary to the burning of biomass fuels
publisher	Ubiquity Press
publishDate	2015
url	https://doaj.org/article/d50da1c5f14d4b7493be502c20fedc6e
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A Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels

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