Maternal enrichment during pregnancy accelerates retinal development of the fetus.

The influence of maternal environment on fetal development is largely unexplored, the available evidence concerns only the deleterious effects elicited by prenatal stress. Here we investigated the influence of prenatal enrichment on the early development of the visual system in the fetus. We studied...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alessandro Sale, Maria Cristina Cenni, Francesca Ciucci, Elena Putignano, Sabrina Chierzi, Lamberto Maffei
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d50fc2a2e7b242fc9717ba08f749abfb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d50fc2a2e7b242fc9717ba08f749abfb
record_format	dspace
spelling	oai:doaj.org-article:d50fc2a2e7b242fc9717ba08f749abfb2021-11-25T06:10:29ZMaternal enrichment during pregnancy accelerates retinal development of the fetus.1932-620310.1371/journal.pone.0001160https://doaj.org/article/d50fc2a2e7b242fc9717ba08f749abfb2007-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0001160https://doaj.org/toc/1932-6203The influence of maternal environment on fetal development is largely unexplored, the available evidence concerns only the deleterious effects elicited by prenatal stress. Here we investigated the influence of prenatal enrichment on the early development of the visual system in the fetus. We studied the anatomical development of the rat retina, by analyzing the migration of neural progenitors and the process of retinal ganglion cell death, which exerts a key role in sculpturing the developing retinal system at perinatal ages. The number of apoptotic cells in the retinal ganglion cell layer was analyzed using two distinct methods: the presence of pyknotic nuclei stained for cresyl violet and the appearance of DNA fragmentation (Tunel method). We report that environmental enrichment of the mother during pregnancy affects the structural maturation of the retina, accelerating the migration of neural progenitors and the dynamics of natural cell death. These effects seem to be under the control of insulin-like growth factor-I: its levels, higher in enriched pregnant rats and in their milk, are increased also in their offspring, its neutralization abolishes the action of maternal enrichment on retinal development and chronic insulin-like growth factor-I injection to standard-reared females mimics the effects of enrichment in the fetuses. Thus, the development of the visual system is sensitive to environmental stimulation during prenatal life. These findings could have a bearing in orienting clinical research in the field of prenatal therapy.Alessandro SaleMaria Cristina CenniFrancesca CiucciElena PutignanoSabrina ChierziLamberto MaffeiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 2, Iss 11, p e1160 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alessandro Sale Maria Cristina Cenni Francesca Ciucci Elena Putignano Sabrina Chierzi Lamberto Maffei Maternal enrichment during pregnancy accelerates retinal development of the fetus.
description	The influence of maternal environment on fetal development is largely unexplored, the available evidence concerns only the deleterious effects elicited by prenatal stress. Here we investigated the influence of prenatal enrichment on the early development of the visual system in the fetus. We studied the anatomical development of the rat retina, by analyzing the migration of neural progenitors and the process of retinal ganglion cell death, which exerts a key role in sculpturing the developing retinal system at perinatal ages. The number of apoptotic cells in the retinal ganglion cell layer was analyzed using two distinct methods: the presence of pyknotic nuclei stained for cresyl violet and the appearance of DNA fragmentation (Tunel method). We report that environmental enrichment of the mother during pregnancy affects the structural maturation of the retina, accelerating the migration of neural progenitors and the dynamics of natural cell death. These effects seem to be under the control of insulin-like growth factor-I: its levels, higher in enriched pregnant rats and in their milk, are increased also in their offspring, its neutralization abolishes the action of maternal enrichment on retinal development and chronic insulin-like growth factor-I injection to standard-reared females mimics the effects of enrichment in the fetuses. Thus, the development of the visual system is sensitive to environmental stimulation during prenatal life. These findings could have a bearing in orienting clinical research in the field of prenatal therapy.
format	article
author	Alessandro Sale Maria Cristina Cenni Francesca Ciucci Elena Putignano Sabrina Chierzi Lamberto Maffei
author_facet	Alessandro Sale Maria Cristina Cenni Francesca Ciucci Elena Putignano Sabrina Chierzi Lamberto Maffei
author_sort	Alessandro Sale
title	Maternal enrichment during pregnancy accelerates retinal development of the fetus.
title_short	Maternal enrichment during pregnancy accelerates retinal development of the fetus.
title_full	Maternal enrichment during pregnancy accelerates retinal development of the fetus.
title_fullStr	Maternal enrichment during pregnancy accelerates retinal development of the fetus.
title_full_unstemmed	Maternal enrichment during pregnancy accelerates retinal development of the fetus.
title_sort	maternal enrichment during pregnancy accelerates retinal development of the fetus.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/d50fc2a2e7b242fc9717ba08f749abfb
work_keys_str_mv	AT alessandrosale maternalenrichmentduringpregnancyacceleratesretinaldevelopmentofthefetus AT mariacristinacenni maternalenrichmentduringpregnancyacceleratesretinaldevelopmentofthefetus AT francescaciucci maternalenrichmentduringpregnancyacceleratesretinaldevelopmentofthefetus AT elenaputignano maternalenrichmentduringpregnancyacceleratesretinaldevelopmentofthefetus AT sabrinachierzi maternalenrichmentduringpregnancyacceleratesretinaldevelopmentofthefetus AT lambertomaffei maternalenrichmentduringpregnancyacceleratesretinaldevelopmentofthefetus
_version_	1718414132137426944

Maternal enrichment during pregnancy accelerates retinal development of the fetus.

Ejemplares similares