Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia
Mutations to the splicing machinery may have an important role in myelodysplasia. Here, the authors describe splicing factor gene mutations in myelodysplasia and report tumor suppressor, epigenetic, iron metabolism and heme biosynthesis genes as their targets.
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Nature Portfolio
2018
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oai:doaj.org-article:d51021625acb4fb6bc05018865814b722021-12-02T15:34:44ZAberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia10.1038/s41467-018-06063-x2041-1723https://doaj.org/article/d51021625acb4fb6bc05018865814b722018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06063-xhttps://doaj.org/toc/2041-1723Mutations to the splicing machinery may have an important role in myelodysplasia. Here, the authors describe splicing factor gene mutations in myelodysplasia and report tumor suppressor, epigenetic, iron metabolism and heme biosynthesis genes as their targets.Yusuke ShiozawaLuca MalcovatiAnna GallìAiko Sato-OtsuboKeisuke KataokaYusuke SatoYosaku WatataniHiromichi SuzukiTetsuichi YoshizatoKenichi YoshidaMasashi SanadaHideki MakishimaYuichi ShiraishiKenichi ChibaEva Hellström-LindbergSatoru MiyanoSeishi OgawaMario CazzolaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
institution |
DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Yusuke Shiozawa Luca Malcovati Anna Gallì Aiko Sato-Otsubo Keisuke Kataoka Yusuke Sato Yosaku Watatani Hiromichi Suzuki Tetsuichi Yoshizato Kenichi Yoshida Masashi Sanada Hideki Makishima Yuichi Shiraishi Kenichi Chiba Eva Hellström-Lindberg Satoru Miyano Seishi Ogawa Mario Cazzola Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia |
description |
Mutations to the splicing machinery may have an important role in myelodysplasia. Here, the authors describe splicing factor gene mutations in myelodysplasia and report tumor suppressor, epigenetic, iron metabolism and heme biosynthesis genes as their targets. |
format |
article |
author |
Yusuke Shiozawa Luca Malcovati Anna Gallì Aiko Sato-Otsubo Keisuke Kataoka Yusuke Sato Yosaku Watatani Hiromichi Suzuki Tetsuichi Yoshizato Kenichi Yoshida Masashi Sanada Hideki Makishima Yuichi Shiraishi Kenichi Chiba Eva Hellström-Lindberg Satoru Miyano Seishi Ogawa Mario Cazzola |
author_facet |
Yusuke Shiozawa Luca Malcovati Anna Gallì Aiko Sato-Otsubo Keisuke Kataoka Yusuke Sato Yosaku Watatani Hiromichi Suzuki Tetsuichi Yoshizato Kenichi Yoshida Masashi Sanada Hideki Makishima Yuichi Shiraishi Kenichi Chiba Eva Hellström-Lindberg Satoru Miyano Seishi Ogawa Mario Cazzola |
author_sort |
Yusuke Shiozawa |
title |
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia |
title_short |
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia |
title_full |
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia |
title_fullStr |
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia |
title_full_unstemmed |
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia |
title_sort |
aberrant splicing and defective mrna production induced by somatic spliceosome mutations in myelodysplasia |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/d51021625acb4fb6bc05018865814b72 |
work_keys_str_mv |
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1718386809571901440 |