Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia

Mutations to the splicing machinery may have an important role in myelodysplasia. Here, the authors describe splicing factor gene mutations in myelodysplasia and report tumor suppressor, epigenetic, iron metabolism and heme biosynthesis genes as their targets.

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Autores principales: Yusuke Shiozawa, Luca Malcovati, Anna Gallì, Aiko Sato-Otsubo, Keisuke Kataoka, Yusuke Sato, Yosaku Watatani, Hiromichi Suzuki, Tetsuichi Yoshizato, Kenichi Yoshida, Masashi Sanada, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Eva Hellström-Lindberg, Satoru Miyano, Seishi Ogawa, Mario Cazzola
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d51021625acb4fb6bc05018865814b72
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spelling oai:doaj.org-article:d51021625acb4fb6bc05018865814b722021-12-02T15:34:44ZAberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia10.1038/s41467-018-06063-x2041-1723https://doaj.org/article/d51021625acb4fb6bc05018865814b722018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06063-xhttps://doaj.org/toc/2041-1723Mutations to the splicing machinery may have an important role in myelodysplasia. Here, the authors describe splicing factor gene mutations in myelodysplasia and report tumor suppressor, epigenetic, iron metabolism and heme biosynthesis genes as their targets.Yusuke ShiozawaLuca MalcovatiAnna GallìAiko Sato-OtsuboKeisuke KataokaYusuke SatoYosaku WatataniHiromichi SuzukiTetsuichi YoshizatoKenichi YoshidaMasashi SanadaHideki MakishimaYuichi ShiraishiKenichi ChibaEva Hellström-LindbergSatoru MiyanoSeishi OgawaMario CazzolaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yusuke Shiozawa
Luca Malcovati
Anna Gallì
Aiko Sato-Otsubo
Keisuke Kataoka
Yusuke Sato
Yosaku Watatani
Hiromichi Suzuki
Tetsuichi Yoshizato
Kenichi Yoshida
Masashi Sanada
Hideki Makishima
Yuichi Shiraishi
Kenichi Chiba
Eva Hellström-Lindberg
Satoru Miyano
Seishi Ogawa
Mario Cazzola
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia
description Mutations to the splicing machinery may have an important role in myelodysplasia. Here, the authors describe splicing factor gene mutations in myelodysplasia and report tumor suppressor, epigenetic, iron metabolism and heme biosynthesis genes as their targets.
format article
author Yusuke Shiozawa
Luca Malcovati
Anna Gallì
Aiko Sato-Otsubo
Keisuke Kataoka
Yusuke Sato
Yosaku Watatani
Hiromichi Suzuki
Tetsuichi Yoshizato
Kenichi Yoshida
Masashi Sanada
Hideki Makishima
Yuichi Shiraishi
Kenichi Chiba
Eva Hellström-Lindberg
Satoru Miyano
Seishi Ogawa
Mario Cazzola
author_facet Yusuke Shiozawa
Luca Malcovati
Anna Gallì
Aiko Sato-Otsubo
Keisuke Kataoka
Yusuke Sato
Yosaku Watatani
Hiromichi Suzuki
Tetsuichi Yoshizato
Kenichi Yoshida
Masashi Sanada
Hideki Makishima
Yuichi Shiraishi
Kenichi Chiba
Eva Hellström-Lindberg
Satoru Miyano
Seishi Ogawa
Mario Cazzola
author_sort Yusuke Shiozawa
title Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia
title_short Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia
title_full Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia
title_fullStr Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia
title_full_unstemmed Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia
title_sort aberrant splicing and defective mrna production induced by somatic spliceosome mutations in myelodysplasia
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d51021625acb4fb6bc05018865814b72
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