Transplanted neurons integrate into adult retinas and respond to light

Replacing lost retinal ganglion cells is a potential treatment for optic neuropathies such as glaucoma. Here, the authors show that transplanted donor RGCs can successfully integrate into a mature host retina in vivo, projecting axons along the intact visual pathway and responding to light stimuli.

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Auteurs principaux:	Praseeda Venugopalan, Yan Wang, Tu Nguyen, Abigail Huang, Kenneth J. Muller, Jeffrey L. Goldberg
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/d510c6c61d334135aba88bebb6041525
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spelling	oai:doaj.org-article:d510c6c61d334135aba88bebb60415252021-12-02T15:34:10ZTransplanted neurons integrate into adult retinas and respond to light10.1038/ncomms104722041-1723https://doaj.org/article/d510c6c61d334135aba88bebb60415252016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10472https://doaj.org/toc/2041-1723Replacing lost retinal ganglion cells is a potential treatment for optic neuropathies such as glaucoma. Here, the authors show that transplanted donor RGCs can successfully integrate into a mature host retina in vivo, projecting axons along the intact visual pathway and responding to light stimuli.Praseeda VenugopalanYan WangTu NguyenAbigail HuangKenneth J. MullerJeffrey L. GoldbergNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Praseeda Venugopalan Yan Wang Tu Nguyen Abigail Huang Kenneth J. Muller Jeffrey L. Goldberg Transplanted neurons integrate into adult retinas and respond to light
description	Replacing lost retinal ganglion cells is a potential treatment for optic neuropathies such as glaucoma. Here, the authors show that transplanted donor RGCs can successfully integrate into a mature host retina in vivo, projecting axons along the intact visual pathway and responding to light stimuli.
format	article
author	Praseeda Venugopalan Yan Wang Tu Nguyen Abigail Huang Kenneth J. Muller Jeffrey L. Goldberg
author_facet	Praseeda Venugopalan Yan Wang Tu Nguyen Abigail Huang Kenneth J. Muller Jeffrey L. Goldberg
author_sort	Praseeda Venugopalan
title	Transplanted neurons integrate into adult retinas and respond to light
title_short	Transplanted neurons integrate into adult retinas and respond to light
title_full	Transplanted neurons integrate into adult retinas and respond to light
title_fullStr	Transplanted neurons integrate into adult retinas and respond to light
title_full_unstemmed	Transplanted neurons integrate into adult retinas and respond to light
title_sort	transplanted neurons integrate into adult retinas and respond to light
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d510c6c61d334135aba88bebb6041525
work_keys_str_mv	AT praseedavenugopalan transplantedneuronsintegrateintoadultretinasandrespondtolight AT yanwang transplantedneuronsintegrateintoadultretinasandrespondtolight AT tunguyen transplantedneuronsintegrateintoadultretinasandrespondtolight AT abigailhuang transplantedneuronsintegrateintoadultretinasandrespondtolight AT kennethjmuller transplantedneuronsintegrateintoadultretinasandrespondtolight AT jeffreylgoldberg transplantedneuronsintegrateintoadultretinasandrespondtolight
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Transplanted neurons integrate into adult retinas and respond to light

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