<italic toggle="yes">In Vivo</italic> Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression

<italic toggle="yes">In Vivo</italic> Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression

ABSTRACT The ectodomain of matrix protein 2 (M2e) of influenza A viruses is a universal influenza A vaccine candidate. Here, we report potential evasion strategies of influenza A viruses under in vivo passive anti-M2e IgG immune selection pressure in severe combined immune-deficient (SCID) mice. A/P...

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Bibliographic Details
Main Authors: Silvie Van den Hoecke, Marlies Ballegeer, Bram Vrancken, Lei Deng, Emma R. Job, Kenny Roose, Bert Schepens, Lien Van Hoecke, Philippe Lemey, Xavier Saelens
Format: article
Language:EN
Published: American Society for Microbiology 2021
Subjects:
influenza
broadly protective
deep sequencing
escape
immunotherapy
monoclonal antibodies
Microbiology
QR1-502
Online Access:https://doaj.org/article/d51386aa0cb244889e4bdf58c40d32b6
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https://doaj.org/article/d51386aa0cb244889e4bdf58c40d32b6

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