Subnanometer-resolution structure determination in situ by hybrid subtomogram averaging - single particle cryo-EM

Combining cryo-electron tomography with subtomogram averaging (StA) allows the in situ structure determination of proteins and protein complexes. Here, the authors present the hybrid StA (hStA) workflow that combines the advantages of single particle cryo-EM and StA and consists of a tomographic dat...

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Bibliographic Details
Main Authors: Ricardo M. Sanchez, Yingyi Zhang, Wenbo Chen, Lea Dietrich, Mikhail Kudryashev
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/d517dfd8abf9429a9e657378002f8d85
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