Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.

Over 95% of the adult population worldwide is infected with Epstein-Barr virus (EBV). EBV infection is associated with the development of several cancers, including Hodgkin lymphoma (HL). Elevated levels of anti-EBV antibodies have been associated with increased risk of HL. There is growing evidence...

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Autores principales:	Vincent Pedergnana, Laurène Syx, Aurélie Cobat, Julien Guergnon, Pauline Brice, Christophe Fermé, Patrice Carde, Olivier Hermine, Catherine Le-Pendeven, Corinne Amiel, Yassine Taoufik, Alexandre Alcaïs, Ioannis Theodorou, Caroline Besson, Laurent Abel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d519758268c44a409713dc620f94975a
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spelling	oai:doaj.org-article:d519758268c44a409713dc620f94975a2021-11-25T06:08:28ZCombined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.1932-620310.1371/journal.pone.0102501https://doaj.org/article/d519758268c44a409713dc620f94975a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25025336/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Over 95% of the adult population worldwide is infected with Epstein-Barr virus (EBV). EBV infection is associated with the development of several cancers, including Hodgkin lymphoma (HL). Elevated levels of anti-EBV antibodies have been associated with increased risk of HL. There is growing evidence that genetic factors control the levels of antibodies against EBV antigens. Here, we conducted linkage and association studies to search for genetic factors influencing either anti-viral capsid antigen (VCA) or anti-Epstein Barr nuclear antigen-1 (EBNA-1) IgG levels in a unique cohort of 424 individuals of European origin from 119 French families recruited through a Hodgkin lymphoma (HL) patient. No major locus controlling anti-VCA antibody levels was identified. However, we found that the HLA region influenced anti-EBNA-1 IgG titers. Refined association studies in this region identified a cluster of HLA class II variants associated with anti-EBNA-1 IgG titers (e.g. p = 5×10(-5) for rs9268403). The major allele of rs9268403 conferring a predisposition to high anti-EBNA-1 antibody levels was also associated with an increased risk of HL (p = 0.02). In summary, this study shows that HLA class II variants influenced anti-EBNA-1 IgG titers in a European population. It further shows the role of the same variants in the risk of HL.Vincent PedergnanaLaurène SyxAurélie CobatJulien GuergnonPauline BriceChristophe FerméPatrice CardeOlivier HermineCatherine Le-PendevenCorinne AmielYassine TaoufikAlexandre AlcaïsIoannis TheodorouCaroline BessonLaurent AbelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e102501 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vincent Pedergnana Laurène Syx Aurélie Cobat Julien Guergnon Pauline Brice Christophe Fermé Patrice Carde Olivier Hermine Catherine Le-Pendeven Corinne Amiel Yassine Taoufik Alexandre Alcaïs Ioannis Theodorou Caroline Besson Laurent Abel Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.
description	Over 95% of the adult population worldwide is infected with Epstein-Barr virus (EBV). EBV infection is associated with the development of several cancers, including Hodgkin lymphoma (HL). Elevated levels of anti-EBV antibodies have been associated with increased risk of HL. There is growing evidence that genetic factors control the levels of antibodies against EBV antigens. Here, we conducted linkage and association studies to search for genetic factors influencing either anti-viral capsid antigen (VCA) or anti-Epstein Barr nuclear antigen-1 (EBNA-1) IgG levels in a unique cohort of 424 individuals of European origin from 119 French families recruited through a Hodgkin lymphoma (HL) patient. No major locus controlling anti-VCA antibody levels was identified. However, we found that the HLA region influenced anti-EBNA-1 IgG titers. Refined association studies in this region identified a cluster of HLA class II variants associated with anti-EBNA-1 IgG titers (e.g. p = 5×10(-5) for rs9268403). The major allele of rs9268403 conferring a predisposition to high anti-EBNA-1 antibody levels was also associated with an increased risk of HL (p = 0.02). In summary, this study shows that HLA class II variants influenced anti-EBNA-1 IgG titers in a European population. It further shows the role of the same variants in the risk of HL.
format	article
author	Vincent Pedergnana Laurène Syx Aurélie Cobat Julien Guergnon Pauline Brice Christophe Fermé Patrice Carde Olivier Hermine Catherine Le-Pendeven Corinne Amiel Yassine Taoufik Alexandre Alcaïs Ioannis Theodorou Caroline Besson Laurent Abel
author_facet	Vincent Pedergnana Laurène Syx Aurélie Cobat Julien Guergnon Pauline Brice Christophe Fermé Patrice Carde Olivier Hermine Catherine Le-Pendeven Corinne Amiel Yassine Taoufik Alexandre Alcaïs Ioannis Theodorou Caroline Besson Laurent Abel
author_sort	Vincent Pedergnana
title	Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.
title_short	Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.
title_full	Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.
title_fullStr	Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.
title_full_unstemmed	Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.
title_sort	combined linkage and association studies show that hla class ii variants control levels of antibodies against epstein-barr virus antigens.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/d519758268c44a409713dc620f94975a
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Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.

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