Prediction of Treatment Response According to ASAS-EULAR Management Recommendations in 1 Year for Hip Involvement in Axial Spondyloarthritis Based on MRI and Clinical Indicators

BackgroundTo predict the treatment response for axial spondyloarthritis (axSpA) with hip involvement in 1 year based on MRI and clinical indicators.MethodsA total of 77 axSpA patients with hip involvement (60 males; median age, 25 years; interquartile, 22–31 years old) were treated with a drug recom...

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Autores principales:	Zhuoyao Xie, Zixiao Lu, Hao Chen, Qiang Ye, Chang Guo, Kai Zheng, Xin Li, Qiuxia Xie, Shaoyong Hu, Quan Zhou, Yinghua Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	magnetic resonance imaging axial spondyloarthritis hip involvement treatment response predictive model Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/d51d2b4c164e4a1fb7f46e560b2c7e09
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spelling	oai:doaj.org-article:d51d2b4c164e4a1fb7f46e560b2c7e092021-11-30T14:31:48ZPrediction of Treatment Response According to ASAS-EULAR Management Recommendations in 1 Year for Hip Involvement in Axial Spondyloarthritis Based on MRI and Clinical Indicators1664-239210.3389/fendo.2021.771997https://doaj.org/article/d51d2b4c164e4a1fb7f46e560b2c7e092021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.771997/fullhttps://doaj.org/toc/1664-2392BackgroundTo predict the treatment response for axial spondyloarthritis (axSpA) with hip involvement in 1 year based on MRI and clinical indicators.MethodsA total of 77 axSpA patients with hip involvement (60 males; median age, 25 years; interquartile, 22–31 years old) were treated with a drug recommended by the Assessment of SpondyloArthritis international Society and the European League Against Rheumatism (ASAS-EULAR) management. They were prospectively enrolled according to Assessment in SpondyloArthritis international Society (ASAS) criteria. Clinical indicators, including age, gender, disease duration, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were collected at baseline and in 3 months to 1-year follow-up. Treatment response was evaluated according to ASAS response criteria. MRI indicators consisting of bone marrow edema (BME) in acetabulum and femoral head, hip effusion, fat deposition, thickened synovium, bone erosion, bone proliferation, muscle involvement, enthesitis and bony ankylosis were assessed at baseline. Spearman’s correlation analysis was utilized for indicator selection. The selected clinical and MRI indicators were integrated with previous clinical knowledge to develop multivariable logistic regression models. Receiver operator characteristic curve and area under the curve (AUC) were used to assess the performance of the constructed models.ResultsThe model combining MR indicators comprising hip effusion, BME in acetabulum and femoral head and clinical indicators consisting of disease duration, ESR and CRP yielded AUC values of 0.811 and 0.753 for the training and validation cohorts, respectively.ConclusionThe model combining MRI and clinical indicators could predict treatment response for axSpA with hip involvement in 1 year.Zhuoyao XieZixiao LuHao ChenQiang YeChang GuoKai ZhengXin LiQiuxia XieShaoyong HuQuan ZhouYinghua ZhaoFrontiers Media S.A.articlemagnetic resonance imagingaxial spondyloarthritiship involvementtreatment responsepredictive modelDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic resonance imaging axial spondyloarthritis hip involvement treatment response predictive model Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	magnetic resonance imaging axial spondyloarthritis hip involvement treatment response predictive model Diseases of the endocrine glands. Clinical endocrinology RC648-665 Zhuoyao Xie Zixiao Lu Hao Chen Qiang Ye Chang Guo Kai Zheng Xin Li Qiuxia Xie Shaoyong Hu Quan Zhou Yinghua Zhao Prediction of Treatment Response According to ASAS-EULAR Management Recommendations in 1 Year for Hip Involvement in Axial Spondyloarthritis Based on MRI and Clinical Indicators
description	BackgroundTo predict the treatment response for axial spondyloarthritis (axSpA) with hip involvement in 1 year based on MRI and clinical indicators.MethodsA total of 77 axSpA patients with hip involvement (60 males; median age, 25 years; interquartile, 22–31 years old) were treated with a drug recommended by the Assessment of SpondyloArthritis international Society and the European League Against Rheumatism (ASAS-EULAR) management. They were prospectively enrolled according to Assessment in SpondyloArthritis international Society (ASAS) criteria. Clinical indicators, including age, gender, disease duration, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were collected at baseline and in 3 months to 1-year follow-up. Treatment response was evaluated according to ASAS response criteria. MRI indicators consisting of bone marrow edema (BME) in acetabulum and femoral head, hip effusion, fat deposition, thickened synovium, bone erosion, bone proliferation, muscle involvement, enthesitis and bony ankylosis were assessed at baseline. Spearman’s correlation analysis was utilized for indicator selection. The selected clinical and MRI indicators were integrated with previous clinical knowledge to develop multivariable logistic regression models. Receiver operator characteristic curve and area under the curve (AUC) were used to assess the performance of the constructed models.ResultsThe model combining MR indicators comprising hip effusion, BME in acetabulum and femoral head and clinical indicators consisting of disease duration, ESR and CRP yielded AUC values of 0.811 and 0.753 for the training and validation cohorts, respectively.ConclusionThe model combining MRI and clinical indicators could predict treatment response for axSpA with hip involvement in 1 year.
format	article
author	Zhuoyao Xie Zixiao Lu Hao Chen Qiang Ye Chang Guo Kai Zheng Xin Li Qiuxia Xie Shaoyong Hu Quan Zhou Yinghua Zhao
author_facet	Zhuoyao Xie Zixiao Lu Hao Chen Qiang Ye Chang Guo Kai Zheng Xin Li Qiuxia Xie Shaoyong Hu Quan Zhou Yinghua Zhao
author_sort	Zhuoyao Xie
title	Prediction of Treatment Response According to ASAS-EULAR Management Recommendations in 1 Year for Hip Involvement in Axial Spondyloarthritis Based on MRI and Clinical Indicators
title_short	Prediction of Treatment Response According to ASAS-EULAR Management Recommendations in 1 Year for Hip Involvement in Axial Spondyloarthritis Based on MRI and Clinical Indicators
title_full	Prediction of Treatment Response According to ASAS-EULAR Management Recommendations in 1 Year for Hip Involvement in Axial Spondyloarthritis Based on MRI and Clinical Indicators
title_fullStr	Prediction of Treatment Response According to ASAS-EULAR Management Recommendations in 1 Year for Hip Involvement in Axial Spondyloarthritis Based on MRI and Clinical Indicators
title_full_unstemmed	Prediction of Treatment Response According to ASAS-EULAR Management Recommendations in 1 Year for Hip Involvement in Axial Spondyloarthritis Based on MRI and Clinical Indicators
title_sort	prediction of treatment response according to asas-eular management recommendations in 1 year for hip involvement in axial spondyloarthritis based on mri and clinical indicators
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d51d2b4c164e4a1fb7f46e560b2c7e09
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Prediction of Treatment Response According to ASAS-EULAR Management Recommendations in 1 Year for Hip Involvement in Axial Spondyloarthritis Based on MRI and Clinical Indicators

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