The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction

Co-infections with Pseudomonas aeruginosa and Staphylococcus aureus are common in cystic fibrosis patients. Here, the authors show that metal depletion induced by a host protein, calprotectin, promotes co-existence of both pathogens by inhibiting production of anti-staphylococcal molecules by P. aer...

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Autores principales: Catherine A. Wakeman, Jessica L. Moore, Michael J. Noto, Yaofang Zhang, Marc D. Singleton, Boone M. Prentice, Benjamin A. Gilston, Ryan S. Doster, Jennifer A. Gaddy, Walter J. Chazin, Richard M. Caprioli, Eric P. Skaar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/d51f678c97f6455c944b4d671341e53f
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Sumario:Co-infections with Pseudomonas aeruginosa and Staphylococcus aureus are common in cystic fibrosis patients. Here, the authors show that metal depletion induced by a host protein, calprotectin, promotes co-existence of both pathogens by inhibiting production of anti-staphylococcal molecules by P. aeruginosa.