IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex

Human enterovirus 71 (EV71) contains an internal ribosome entry site (IRES) that promotes translation of viral RNA. Here the authors show that an antiviral small molecule DMA-135 binds to the EV71 IRES RNA, inducing conformational change and stabilizing a ternary complex to repress translation.

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Autores principales:	Jesse Davila-Calderon, Neeraj N. Patwardhan, Liang-Yuan Chiu, Andrew Sugarman, Zhengguo Cai, Srinivasa R. Penutmutchu, Mei-Ling Li, Gary Brewer, Amanda E. Hargrove, Blanton S. Tolbert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d51fcb6310e94966bfd95fb336390ef7
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spelling	oai:doaj.org-article:d51fcb6310e94966bfd95fb336390ef72021-12-02T17:26:56ZIRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex10.1038/s41467-020-18594-32041-1723https://doaj.org/article/d51fcb6310e94966bfd95fb336390ef72020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18594-3https://doaj.org/toc/2041-1723Human enterovirus 71 (EV71) contains an internal ribosome entry site (IRES) that promotes translation of viral RNA. Here the authors show that an antiviral small molecule DMA-135 binds to the EV71 IRES RNA, inducing conformational change and stabilizing a ternary complex to repress translation.Jesse Davila-CalderonNeeraj N. PatwardhanLiang-Yuan ChiuAndrew SugarmanZhengguo CaiSrinivasa R. PenutmutchuMei-Ling LiGary BrewerAmanda E. HargroveBlanton S. TolbertNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jesse Davila-Calderon Neeraj N. Patwardhan Liang-Yuan Chiu Andrew Sugarman Zhengguo Cai Srinivasa R. Penutmutchu Mei-Ling Li Gary Brewer Amanda E. Hargrove Blanton S. Tolbert IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
description	Human enterovirus 71 (EV71) contains an internal ribosome entry site (IRES) that promotes translation of viral RNA. Here the authors show that an antiviral small molecule DMA-135 binds to the EV71 IRES RNA, inducing conformational change and stabilizing a ternary complex to repress translation.
format	article
author	Jesse Davila-Calderon Neeraj N. Patwardhan Liang-Yuan Chiu Andrew Sugarman Zhengguo Cai Srinivasa R. Penutmutchu Mei-Ling Li Gary Brewer Amanda E. Hargrove Blanton S. Tolbert
author_facet	Jesse Davila-Calderon Neeraj N. Patwardhan Liang-Yuan Chiu Andrew Sugarman Zhengguo Cai Srinivasa R. Penutmutchu Mei-Ling Li Gary Brewer Amanda E. Hargrove Blanton S. Tolbert
author_sort	Jesse Davila-Calderon
title	IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
title_short	IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
title_full	IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
title_fullStr	IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
title_full_unstemmed	IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
title_sort	ires-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d51fcb6310e94966bfd95fb336390ef7
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IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex

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