Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation
Inflammation can promote cartilage degradation by inducing matrix-degrading enzymes via NF-κB. Here the authors uncover reciprocal inhibition of Yap/Taz and NF-κB signaling though TAK1, and identify Yap activity as critical for maintenance of cartilage integrity in a mouse model of osteoarthritis.
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Nature Portfolio
2018
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oai:doaj.org-article:d52048cf054c48528cb5a67044142ce72021-12-02T14:39:08ZReciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation10.1038/s41467-018-07022-22041-1723https://doaj.org/article/d52048cf054c48528cb5a67044142ce72018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07022-2https://doaj.org/toc/2041-1723Inflammation can promote cartilage degradation by inducing matrix-degrading enzymes via NF-κB. Here the authors uncover reciprocal inhibition of Yap/Taz and NF-κB signaling though TAK1, and identify Yap activity as critical for maintenance of cartilage integrity in a mouse model of osteoarthritis.Yujie DengJinqiu LuWenling LiAiling WuXu ZhangWenxue TongKiwai Kevin HoLing QinHai SongKinglun Kingston MakNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yujie Deng Jinqiu Lu Wenling Li Ailing Wu Xu Zhang Wenxue Tong Kiwai Kevin Ho Ling Qin Hai Song Kinglun Kingston Mak Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation |
| description |
Inflammation can promote cartilage degradation by inducing matrix-degrading enzymes via NF-κB. Here the authors uncover reciprocal inhibition of Yap/Taz and NF-κB signaling though TAK1, and identify Yap activity as critical for maintenance of cartilage integrity in a mouse model of osteoarthritis. |
| format |
article |
| author |
Yujie Deng Jinqiu Lu Wenling Li Ailing Wu Xu Zhang Wenxue Tong Kiwai Kevin Ho Ling Qin Hai Song Kinglun Kingston Mak |
| author_facet |
Yujie Deng Jinqiu Lu Wenling Li Ailing Wu Xu Zhang Wenxue Tong Kiwai Kevin Ho Ling Qin Hai Song Kinglun Kingston Mak |
| author_sort |
Yujie Deng |
| title |
Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation |
| title_short |
Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation |
| title_full |
Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation |
| title_fullStr |
Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation |
| title_full_unstemmed |
Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation |
| title_sort |
reciprocal inhibition of yap/taz and nf-κb regulates osteoarthritic cartilage degradation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/d52048cf054c48528cb5a67044142ce7 |
| work_keys_str_mv |
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| _version_ |
1718390739867533312 |