Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review

Kidney transplantation is the preferred treatment for end-stage kidney disease. It is, however, not devoid of complications. Delayed graft function related to ischemia-reperfusion injury (IRI), calcineurin inhibitor (CNI) nephrotoxicity, diabetes, and a particularly high-rate cardiovascular disease...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nicolas I. Bustos, Camilo G. Sotomayor, Robert A. Pol, Gerjan J. Navis, Stephan J. L. Bakker
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	polyphenols resveratrol kidney transplantation delayed graft function reperfusion injury calcineurin inhibitors Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/d520b8e083bf47e0921ec65cdd5c75dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d520b8e083bf47e0921ec65cdd5c75dd
record_format	dspace
spelling	oai:doaj.org-article:d520b8e083bf47e0921ec65cdd5c75dd2021-11-16T05:27:27ZPolyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review2297-055X10.3389/fcvm.2021.751036https://doaj.org/article/d520b8e083bf47e0921ec65cdd5c75dd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.751036/fullhttps://doaj.org/toc/2297-055XKidney transplantation is the preferred treatment for end-stage kidney disease. It is, however, not devoid of complications. Delayed graft function related to ischemia-reperfusion injury (IRI), calcineurin inhibitor (CNI) nephrotoxicity, diabetes, and a particularly high-rate cardiovascular disease (CVD) risk, represent important complications following kidney transplantation. Oxidative stress and chronic low-grade inflammation are mechanisms of disease incompletely abrogated in stable kidney transplant recipient (KTR), contributing to the occurrence of these complications. Polyphenols, bioactive compounds with recognized antioxidant and anti-inflammatory properties have been strongly associated with prevention of CVD in the general population and have been shown to decrease IRI and antagonize CNI nephrotoxicity in animal experimental models, therefore they may have a role in prevention of complications in KTR. This narrative review aims to summarize and discuss current evidence on different polyphenols for prevention of complications, particularly prevention of CVD in KTR, pointing toward the need of further studies with potential clinical impact.Nicolas I. BustosCamilo G. SotomayorCamilo G. SotomayorCamilo G. SotomayorRobert A. PolGerjan J. NavisStephan J. L. BakkerFrontiers Media S.A.articlepolyphenolsresveratrolkidney transplantationdelayed graft functionreperfusion injurycalcineurin inhibitorsDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyphenols resveratrol kidney transplantation delayed graft function reperfusion injury calcineurin inhibitors Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	polyphenols resveratrol kidney transplantation delayed graft function reperfusion injury calcineurin inhibitors Diseases of the circulatory (Cardiovascular) system RC666-701 Nicolas I. Bustos Camilo G. Sotomayor Camilo G. Sotomayor Camilo G. Sotomayor Robert A. Pol Gerjan J. Navis Stephan J. L. Bakker Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review
description	Kidney transplantation is the preferred treatment for end-stage kidney disease. It is, however, not devoid of complications. Delayed graft function related to ischemia-reperfusion injury (IRI), calcineurin inhibitor (CNI) nephrotoxicity, diabetes, and a particularly high-rate cardiovascular disease (CVD) risk, represent important complications following kidney transplantation. Oxidative stress and chronic low-grade inflammation are mechanisms of disease incompletely abrogated in stable kidney transplant recipient (KTR), contributing to the occurrence of these complications. Polyphenols, bioactive compounds with recognized antioxidant and anti-inflammatory properties have been strongly associated with prevention of CVD in the general population and have been shown to decrease IRI and antagonize CNI nephrotoxicity in animal experimental models, therefore they may have a role in prevention of complications in KTR. This narrative review aims to summarize and discuss current evidence on different polyphenols for prevention of complications, particularly prevention of CVD in KTR, pointing toward the need of further studies with potential clinical impact.
format	article
author	Nicolas I. Bustos Camilo G. Sotomayor Camilo G. Sotomayor Camilo G. Sotomayor Robert A. Pol Gerjan J. Navis Stephan J. L. Bakker
author_facet	Nicolas I. Bustos Camilo G. Sotomayor Camilo G. Sotomayor Camilo G. Sotomayor Robert A. Pol Gerjan J. Navis Stephan J. L. Bakker
author_sort	Nicolas I. Bustos
title	Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review
title_short	Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review
title_full	Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review
title_fullStr	Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review
title_full_unstemmed	Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review
title_sort	polyphenols and novel insights into post-kidney transplant complications and cardiovascular disease: a narrative review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d520b8e083bf47e0921ec65cdd5c75dd
work_keys_str_mv	AT nicolasibustos polyphenolsandnovelinsightsintopostkidneytransplantcomplicationsandcardiovasculardiseaseanarrativereview AT camilogsotomayor polyphenolsandnovelinsightsintopostkidneytransplantcomplicationsandcardiovasculardiseaseanarrativereview AT camilogsotomayor polyphenolsandnovelinsightsintopostkidneytransplantcomplicationsandcardiovasculardiseaseanarrativereview AT camilogsotomayor polyphenolsandnovelinsightsintopostkidneytransplantcomplicationsandcardiovasculardiseaseanarrativereview AT robertapol polyphenolsandnovelinsightsintopostkidneytransplantcomplicationsandcardiovasculardiseaseanarrativereview AT gerjanjnavis polyphenolsandnovelinsightsintopostkidneytransplantcomplicationsandcardiovasculardiseaseanarrativereview AT stephanjlbakker polyphenolsandnovelinsightsintopostkidneytransplantcomplicationsandcardiovasculardiseaseanarrativereview
_version_	1718426694653575168

Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review

Ejemplares similares