An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository

Aim. The study is aimed at developing curcumin suppositories as a promising approach for natural antifungal management of vaginal candidiasis in cervical cancer patients to eradicate side effects produced by current antifungal drugs. The objective of the study was to optimize the suppositories using...

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Autores principales:	Mohammed Ghazwani, Umme Hani, Riyaz Ali M. Osmani, Mohamed Rahamathulla, M. Yasmin Begum, Shadma Wahab, D. V. Gowda, Akhila Akkihebbal Ravikumar, Honnavalli Yogish kumar, Hissana Ather, Afrasim Moin
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/d5211c7676dd40d7b93ba2aabe1018b8
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spelling	oai:doaj.org-article:d5211c7676dd40d7b93ba2aabe1018b82021-11-15T01:20:09ZAn Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository1687-943010.1155/2021/9198387https://doaj.org/article/d5211c7676dd40d7b93ba2aabe1018b82021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9198387https://doaj.org/toc/1687-9430Aim. The study is aimed at developing curcumin suppositories as a promising approach for natural antifungal management of vaginal candidiasis in cervical cancer patients to eradicate side effects produced by current antifungal drugs. The objective of the study was to optimize the suppositories using optimal (custom) design employing Design-Expert 13 software to recognize the concentration of polyethylene glycols (PEG) and Poloxamer 407 and obtain a stable suppository. Methodology. Combinations of PEG 1500 (10%–40%), PEG 6000 (40%–60%), and Poloxamer 407 (5%–30%) were entered as factors, and the responses evaluated were hardness, deformation time, and % drug release. In addition, the formulation was also evaluated for visual examination, weight variation, pH determination, drug content, hardness test, disintegration time, melting zone, deformation time, in vitro drug release, antifungal activity, and stability tests. Results. Suppositories were devoid of holes and cracks, with a characteristic odor and a dark yellowish-orange color. All formulations passed the weight variation test. Formulations exhibited pH ranging from 5.5 to 6.5. Drug content was observed to be 98.65±0.041%–99.85±0.041%. The hardness of the formulation was between 2.9 and 4.2 kg/cm2. The disintegration time ranged from 11±0.052 min to 20±0.011 min. The melting point was between 41±0.31°C and 58±0.62°C. Deformation time ranged from 10±0.45 to 35±0.52 min. Most of the formulations resulted in 90% of drug release at 40 min, and the zone of inhibition noted was 19.6±0.4 mm. All the selected factors have a significant effect on the response chosen for the study. Conclusion. The optimized curcumin vaginal suppository formulation can be an efficient herbal treatment devoid of side effects to treat vaginal candidiasis in cervical cancer patients.Mohammed GhazwaniUmme HaniRiyaz Ali M. OsmaniMohamed RahamathullaM. Yasmin BegumShadma WahabD. V. GowdaAkhila Akkihebbal RavikumarHonnavalli Yogish kumarHissana AtherAfrasim MoinHindawi LimitedarticleChemical technologyTP1-1185ENInternational Journal of Polymer Science, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemical technology TP1-1185
spellingShingle	Chemical technology TP1-1185 Mohammed Ghazwani Umme Hani Riyaz Ali M. Osmani Mohamed Rahamathulla M. Yasmin Begum Shadma Wahab D. V. Gowda Akhila Akkihebbal Ravikumar Honnavalli Yogish kumar Hissana Ather Afrasim Moin An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository
description	Aim. The study is aimed at developing curcumin suppositories as a promising approach for natural antifungal management of vaginal candidiasis in cervical cancer patients to eradicate side effects produced by current antifungal drugs. The objective of the study was to optimize the suppositories using optimal (custom) design employing Design-Expert 13 software to recognize the concentration of polyethylene glycols (PEG) and Poloxamer 407 and obtain a stable suppository. Methodology. Combinations of PEG 1500 (10%–40%), PEG 6000 (40%–60%), and Poloxamer 407 (5%–30%) were entered as factors, and the responses evaluated were hardness, deformation time, and % drug release. In addition, the formulation was also evaluated for visual examination, weight variation, pH determination, drug content, hardness test, disintegration time, melting zone, deformation time, in vitro drug release, antifungal activity, and stability tests. Results. Suppositories were devoid of holes and cracks, with a characteristic odor and a dark yellowish-orange color. All formulations passed the weight variation test. Formulations exhibited pH ranging from 5.5 to 6.5. Drug content was observed to be 98.65±0.041%–99.85±0.041%. The hardness of the formulation was between 2.9 and 4.2 kg/cm2. The disintegration time ranged from 11±0.052 min to 20±0.011 min. The melting point was between 41±0.31°C and 58±0.62°C. Deformation time ranged from 10±0.45 to 35±0.52 min. Most of the formulations resulted in 90% of drug release at 40 min, and the zone of inhibition noted was 19.6±0.4 mm. All the selected factors have a significant effect on the response chosen for the study. Conclusion. The optimized curcumin vaginal suppository formulation can be an efficient herbal treatment devoid of side effects to treat vaginal candidiasis in cervical cancer patients.
format	article
author	Mohammed Ghazwani Umme Hani Riyaz Ali M. Osmani Mohamed Rahamathulla M. Yasmin Begum Shadma Wahab D. V. Gowda Akhila Akkihebbal Ravikumar Honnavalli Yogish kumar Hissana Ather Afrasim Moin
author_facet	Mohammed Ghazwani Umme Hani Riyaz Ali M. Osmani Mohamed Rahamathulla M. Yasmin Begum Shadma Wahab D. V. Gowda Akhila Akkihebbal Ravikumar Honnavalli Yogish kumar Hissana Ather Afrasim Moin
author_sort	Mohammed Ghazwani
title	An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository
title_short	An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository
title_full	An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository
title_fullStr	An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository
title_full_unstemmed	An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository
title_sort	efficient herbal approach for treating fungal infection in cervical cancer patients by developing and optimizing a vaginal suppository
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/d5211c7676dd40d7b93ba2aabe1018b8
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An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository

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