Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

Galectin-9 regulates several cellular processes including TIM-3-mediated T cell death. Here the authors show that co-expressed PD-1 protects TIM-3+ T cells from galectin-9-induced cell death and that anti-galectin-9 in combination with GITR agonism promotes an anti-tumor immune response.

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Autores principales:	Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Jun Yao, Hui Li, Meisi Yan, Wei-Chao Chang, Jung-Mao Hsu, Jong-Ho Cha, Jennifer L. Hsu, Cheng-Wei Chou, Xian Sun, Yalan Deng, Chao-Kai Chou, Dihua Yu, Mien-Chie Hung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d523a90c2f74464eb447b3b58eea546f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d523a90c2f74464eb447b3b58eea546f2021-12-02T14:06:22ZGalectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy10.1038/s41467-021-21099-22041-1723https://doaj.org/article/d523a90c2f74464eb447b3b58eea546f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21099-2https://doaj.org/toc/2041-1723Galectin-9 regulates several cellular processes including TIM-3-mediated T cell death. Here the authors show that co-expressed PD-1 protects TIM-3+ T cells from galectin-9-induced cell death and that anti-galectin-9 in combination with GITR agonism promotes an anti-tumor immune response.Riyao YangLinlin SunChing-Fei LiYu-Han WangJun YaoHui LiMeisi YanWei-Chao ChangJung-Mao HsuJong-Ho ChaJennifer L. HsuCheng-Wei ChouXian SunYalan DengChao-Kai ChouDihua YuMien-Chie HungNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Riyao Yang Linlin Sun Ching-Fei Li Yu-Han Wang Jun Yao Hui Li Meisi Yan Wei-Chao Chang Jung-Mao Hsu Jong-Ho Cha Jennifer L. Hsu Cheng-Wei Chou Xian Sun Yalan Deng Chao-Kai Chou Dihua Yu Mien-Chie Hung Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
description	Galectin-9 regulates several cellular processes including TIM-3-mediated T cell death. Here the authors show that co-expressed PD-1 protects TIM-3+ T cells from galectin-9-induced cell death and that anti-galectin-9 in combination with GITR agonism promotes an anti-tumor immune response.
format	article
author	Riyao Yang Linlin Sun Ching-Fei Li Yu-Han Wang Jun Yao Hui Li Meisi Yan Wei-Chao Chang Jung-Mao Hsu Jong-Ho Cha Jennifer L. Hsu Cheng-Wei Chou Xian Sun Yalan Deng Chao-Kai Chou Dihua Yu Mien-Chie Hung
author_facet	Riyao Yang Linlin Sun Ching-Fei Li Yu-Han Wang Jun Yao Hui Li Meisi Yan Wei-Chao Chang Jung-Mao Hsu Jong-Ho Cha Jennifer L. Hsu Cheng-Wei Chou Xian Sun Yalan Deng Chao-Kai Chou Dihua Yu Mien-Chie Hung
author_sort	Riyao Yang
title	Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
title_short	Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
title_full	Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
title_fullStr	Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
title_full_unstemmed	Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
title_sort	galectin-9 interacts with pd-1 and tim-3 to regulate t cell death and is a target for cancer immunotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d523a90c2f74464eb447b3b58eea546f
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Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

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