Rapid generation of hypomorphic mutations

Hypomorphic mutations are a valuable tool for analysing gene function, but current methods have difficult to predict effects on gene expression and are organism specific. Here the authors present a pan-species approach using variable polyA tracks to modulate expression of a target protein.

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Detalles Bibliográficos
Autores principales:	Laura L. Arthur, Joyce J. Chung, Preetam Janakirama, Kathryn M. Keefer, Igor Kolotilin, Slavica Pavlovic-Djuranovic, Douglas L. Chalker, Vojislava Grbic, Rachel Green, Rima Menassa, Heather L. True, James B. Skeath, Sergej Djuranovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d5276f10700a4a45bc605bc24297890b
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spelling	oai:doaj.org-article:d5276f10700a4a45bc605bc24297890b2021-12-02T14:40:47ZRapid generation of hypomorphic mutations10.1038/ncomms141122041-1723https://doaj.org/article/d5276f10700a4a45bc605bc24297890b2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14112https://doaj.org/toc/2041-1723Hypomorphic mutations are a valuable tool for analysing gene function, but current methods have difficult to predict effects on gene expression and are organism specific. Here the authors present a pan-species approach using variable polyA tracks to modulate expression of a target protein.Laura L. ArthurJoyce J. ChungPreetam JanakiramaKathryn M. KeeferIgor KolotilinSlavica Pavlovic-DjuranovicDouglas L. ChalkerVojislava GrbicRachel GreenRima MenassaHeather L. TrueJames B. SkeathSergej DjuranovicNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura L. Arthur Joyce J. Chung Preetam Janakirama Kathryn M. Keefer Igor Kolotilin Slavica Pavlovic-Djuranovic Douglas L. Chalker Vojislava Grbic Rachel Green Rima Menassa Heather L. True James B. Skeath Sergej Djuranovic Rapid generation of hypomorphic mutations
description	Hypomorphic mutations are a valuable tool for analysing gene function, but current methods have difficult to predict effects on gene expression and are organism specific. Here the authors present a pan-species approach using variable polyA tracks to modulate expression of a target protein.
format	article
author	Laura L. Arthur Joyce J. Chung Preetam Janakirama Kathryn M. Keefer Igor Kolotilin Slavica Pavlovic-Djuranovic Douglas L. Chalker Vojislava Grbic Rachel Green Rima Menassa Heather L. True James B. Skeath Sergej Djuranovic
author_facet	Laura L. Arthur Joyce J. Chung Preetam Janakirama Kathryn M. Keefer Igor Kolotilin Slavica Pavlovic-Djuranovic Douglas L. Chalker Vojislava Grbic Rachel Green Rima Menassa Heather L. True James B. Skeath Sergej Djuranovic
author_sort	Laura L. Arthur
title	Rapid generation of hypomorphic mutations
title_short	Rapid generation of hypomorphic mutations
title_full	Rapid generation of hypomorphic mutations
title_fullStr	Rapid generation of hypomorphic mutations
title_full_unstemmed	Rapid generation of hypomorphic mutations
title_sort	rapid generation of hypomorphic mutations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d5276f10700a4a45bc605bc24297890b
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Rapid generation of hypomorphic mutations

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