Association between Sleep, Alzheimer’s, and Parkinson’s Disease

The majority of neurodegenerative diseases are pathologically associated with protein misfolding and aggregation. Alzheimer’s disease (AD) is a type of dementia that slowly affects memory and cognitive function, and is characterized by the aggregation of the β-amyloid protein and tau neurofibrillary...

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Autores principales:	Sumire Matsumoto, Tomomi Tsunematsu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease Parkinson’s disease β-amyloid tau neurofibrillary tangles α-synuclein sleep Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d527a4a5904e4e9784cae55e7bc4a2e5
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spelling	oai:doaj.org-article:d527a4a5904e4e9784cae55e7bc4a2e52021-11-25T16:47:18ZAssociation between Sleep, Alzheimer’s, and Parkinson’s Disease10.3390/biology101111272079-7737https://doaj.org/article/d527a4a5904e4e9784cae55e7bc4a2e52021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1127https://doaj.org/toc/2079-7737The majority of neurodegenerative diseases are pathologically associated with protein misfolding and aggregation. Alzheimer’s disease (AD) is a type of dementia that slowly affects memory and cognitive function, and is characterized by the aggregation of the β-amyloid protein and tau neurofibrillary tangles in the brain. Parkinson’s disease (PD) is a movement disorder typically resulting in rigidity and tremor, which is pathologically linked to the aggregation of α-synuclein, particularly in dopaminergic neurons in the midbrain. Sleep disorders commonly occur in AD and PD patients, and it can precede the onset of these diseases. For example, cognitively normal older individuals who have highly fragmented sleep had a 1.5-fold increased risk of subsequently developing AD. This suggests that sleep abnormalities may be a potential biomarker of these diseases. In this review, we describe the alterations of sleep in AD and PD, and discuss their potential in the early diagnosis of these diseases. We further discuss whether sleep disturbance could be a target for the treatment of these diseases.Sumire MatsumotoTomomi TsunematsuMDPI AGarticleAlzheimer’s diseaseParkinson’s diseaseβ-amyloidtau neurofibrillary tanglesα-synucleinsleepBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1127, p 1127 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease Parkinson’s disease β-amyloid tau neurofibrillary tangles α-synuclein sleep Biology (General) QH301-705.5
spellingShingle	Alzheimer’s disease Parkinson’s disease β-amyloid tau neurofibrillary tangles α-synuclein sleep Biology (General) QH301-705.5 Sumire Matsumoto Tomomi Tsunematsu Association between Sleep, Alzheimer’s, and Parkinson’s Disease
description	The majority of neurodegenerative diseases are pathologically associated with protein misfolding and aggregation. Alzheimer’s disease (AD) is a type of dementia that slowly affects memory and cognitive function, and is characterized by the aggregation of the β-amyloid protein and tau neurofibrillary tangles in the brain. Parkinson’s disease (PD) is a movement disorder typically resulting in rigidity and tremor, which is pathologically linked to the aggregation of α-synuclein, particularly in dopaminergic neurons in the midbrain. Sleep disorders commonly occur in AD and PD patients, and it can precede the onset of these diseases. For example, cognitively normal older individuals who have highly fragmented sleep had a 1.5-fold increased risk of subsequently developing AD. This suggests that sleep abnormalities may be a potential biomarker of these diseases. In this review, we describe the alterations of sleep in AD and PD, and discuss their potential in the early diagnosis of these diseases. We further discuss whether sleep disturbance could be a target for the treatment of these diseases.
format	article
author	Sumire Matsumoto Tomomi Tsunematsu
author_facet	Sumire Matsumoto Tomomi Tsunematsu
author_sort	Sumire Matsumoto
title	Association between Sleep, Alzheimer’s, and Parkinson’s Disease
title_short	Association between Sleep, Alzheimer’s, and Parkinson’s Disease
title_full	Association between Sleep, Alzheimer’s, and Parkinson’s Disease
title_fullStr	Association between Sleep, Alzheimer’s, and Parkinson’s Disease
title_full_unstemmed	Association between Sleep, Alzheimer’s, and Parkinson’s Disease
title_sort	association between sleep, alzheimer’s, and parkinson’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d527a4a5904e4e9784cae55e7bc4a2e5
work_keys_str_mv	AT sumirematsumoto associationbetweensleepalzheimersandparkinsonsdisease AT tomomitsunematsu associationbetweensleepalzheimersandparkinsonsdisease
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Association between Sleep, Alzheimer’s, and Parkinson’s Disease

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