RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

A central antiviral defence is immune recognition of cystolic DNA. Here the authors show that RPA and RAD51, in cooperation with TREX1, function to protect the cytosol from self-DNA.

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Autores principales: Christine Wolf, Alexander Rapp, Nicole Berndt, Wolfgang Staroske, Max Schuster, Manuela Dobrick-Mattheuer, Stefanie Kretschmer, Nadja König, Thomas Kurth, Dagmar Wieczorek, Karin Kast, M. Cristina Cardoso, Claudia Günther, Min Ae Lee-Kirsch
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/d52a3f8c27194a7f946279b592b29faa
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spelling oai:doaj.org-article:d52a3f8c27194a7f946279b592b29faa2021-12-02T14:39:13ZRPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA10.1038/ncomms117522041-1723https://doaj.org/article/d52a3f8c27194a7f946279b592b29faa2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11752https://doaj.org/toc/2041-1723A central antiviral defence is immune recognition of cystolic DNA. Here the authors show that RPA and RAD51, in cooperation with TREX1, function to protect the cytosol from self-DNA.Christine WolfAlexander RappNicole BerndtWolfgang StaroskeMax SchusterManuela Dobrick-MattheuerStefanie KretschmerNadja KönigThomas KurthDagmar WieczorekKarin KastM. Cristina CardosoClaudia GüntherMin Ae Lee-KirschNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Christine Wolf
Alexander Rapp
Nicole Berndt
Wolfgang Staroske
Max Schuster
Manuela Dobrick-Mattheuer
Stefanie Kretschmer
Nadja König
Thomas Kurth
Dagmar Wieczorek
Karin Kast
M. Cristina Cardoso
Claudia Günther
Min Ae Lee-Kirsch
RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA
description A central antiviral defence is immune recognition of cystolic DNA. Here the authors show that RPA and RAD51, in cooperation with TREX1, function to protect the cytosol from self-DNA.
format article
author Christine Wolf
Alexander Rapp
Nicole Berndt
Wolfgang Staroske
Max Schuster
Manuela Dobrick-Mattheuer
Stefanie Kretschmer
Nadja König
Thomas Kurth
Dagmar Wieczorek
Karin Kast
M. Cristina Cardoso
Claudia Günther
Min Ae Lee-Kirsch
author_facet Christine Wolf
Alexander Rapp
Nicole Berndt
Wolfgang Staroske
Max Schuster
Manuela Dobrick-Mattheuer
Stefanie Kretschmer
Nadja König
Thomas Kurth
Dagmar Wieczorek
Karin Kast
M. Cristina Cardoso
Claudia Günther
Min Ae Lee-Kirsch
author_sort Christine Wolf
title RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA
title_short RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA
title_full RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA
title_fullStr RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA
title_full_unstemmed RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA
title_sort rpa and rad51 constitute a cell intrinsic mechanism to protect the cytosol from self dna
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/d52a3f8c27194a7f946279b592b29faa
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