Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

FoxO are commonly down-regulated transcription factors and tumor suppressors in renal cell cancer (RCC). Here, the authors show that upon energy stress FoxOs induce the expression of the long non-coding RNA FILNC1, which inhibits survival of RCC by downregulating c-Myc and c-Myc-dependent metabolic...

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Autores principales:	Zhen-Dong Xiao, Leng Han, Hyemin Lee, Li Zhuang, Yilei Zhang, Joelle Baddour, Deepak Nagrath, Christopher G. Wood, Jian Gu, Xifeng Wu, Han Liang, Boyi Gan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d52cbc814c434f93b3293211e3737a33
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spelling	oai:doaj.org-article:d52cbc814c434f93b3293211e3737a332021-12-02T16:51:52ZEnergy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development10.1038/s41467-017-00902-z2041-1723https://doaj.org/article/d52cbc814c434f93b3293211e3737a332017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00902-zhttps://doaj.org/toc/2041-1723FoxO are commonly down-regulated transcription factors and tumor suppressors in renal cell cancer (RCC). Here, the authors show that upon energy stress FoxOs induce the expression of the long non-coding RNA FILNC1, which inhibits survival of RCC by downregulating c-Myc and c-Myc-dependent metabolic rewiring.Zhen-Dong XiaoLeng HanHyemin LeeLi ZhuangYilei ZhangJoelle BaddourDeepak NagrathChristopher G. WoodJian GuXifeng WuHan LiangBoyi GanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhen-Dong Xiao Leng Han Hyemin Lee Li Zhuang Yilei Zhang Joelle Baddour Deepak Nagrath Christopher G. Wood Jian Gu Xifeng Wu Han Liang Boyi Gan Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
description	FoxO are commonly down-regulated transcription factors and tumor suppressors in renal cell cancer (RCC). Here, the authors show that upon energy stress FoxOs induce the expression of the long non-coding RNA FILNC1, which inhibits survival of RCC by downregulating c-Myc and c-Myc-dependent metabolic rewiring.
format	article
author	Zhen-Dong Xiao Leng Han Hyemin Lee Li Zhuang Yilei Zhang Joelle Baddour Deepak Nagrath Christopher G. Wood Jian Gu Xifeng Wu Han Liang Boyi Gan
author_facet	Zhen-Dong Xiao Leng Han Hyemin Lee Li Zhuang Yilei Zhang Joelle Baddour Deepak Nagrath Christopher G. Wood Jian Gu Xifeng Wu Han Liang Boyi Gan
author_sort	Zhen-Dong Xiao
title	Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
title_short	Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
title_full	Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
title_fullStr	Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
title_full_unstemmed	Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
title_sort	energy stress-induced lncrna filnc1 represses c-myc-mediated energy metabolism and inhibits renal tumor development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d52cbc814c434f93b3293211e3737a33
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Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

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