Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates

Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates

Genetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Olena Kis, Rayan Kaedbey, Signy Chow, Arnavaz Danesh, Mark Dowar, Tiantian Li, Zhihua Li, Jessica Liu, Mark Mansour, Esther Masih-Khan, Tong Zhang, Scott V. Bratman, Amit M. Oza, Suzanne Kamel-Reid, Suzanne Trudel, Trevor J. Pugh
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/d52e507d56a94e48a45f62b403d8d6ed
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
Description
Résumé:Genetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.

Documents similaires