Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates

Genetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.

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Autores principales:	Olena Kis, Rayan Kaedbey, Signy Chow, Arnavaz Danesh, Mark Dowar, Tiantian Li, Zhihua Li, Jessica Liu, Mark Mansour, Esther Masih-Khan, Tong Zhang, Scott V. Bratman, Amit M. Oza, Suzanne Kamel-Reid, Suzanne Trudel, Trevor J. Pugh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d52e507d56a94e48a45f62b403d8d6ed
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spelling	oai:doaj.org-article:d52e507d56a94e48a45f62b403d8d6ed2021-12-02T15:39:05ZCirculating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates10.1038/ncomms150862041-1723https://doaj.org/article/d52e507d56a94e48a45f62b403d8d6ed2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15086https://doaj.org/toc/2041-1723Genetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.Olena KisRayan KaedbeySigny ChowArnavaz DaneshMark DowarTiantian LiZhihua LiJessica LiuMark MansourEsther Masih-KhanTong ZhangScott V. BratmanAmit M. OzaSuzanne Kamel-ReidSuzanne TrudelTrevor J. PughNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Olena Kis Rayan Kaedbey Signy Chow Arnavaz Danesh Mark Dowar Tiantian Li Zhihua Li Jessica Liu Mark Mansour Esther Masih-Khan Tong Zhang Scott V. Bratman Amit M. Oza Suzanne Kamel-Reid Suzanne Trudel Trevor J. Pugh Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
description	Genetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.
format	article
author	Olena Kis Rayan Kaedbey Signy Chow Arnavaz Danesh Mark Dowar Tiantian Li Zhihua Li Jessica Liu Mark Mansour Esther Masih-Khan Tong Zhang Scott V. Bratman Amit M. Oza Suzanne Kamel-Reid Suzanne Trudel Trevor J. Pugh
author_facet	Olena Kis Rayan Kaedbey Signy Chow Arnavaz Danesh Mark Dowar Tiantian Li Zhihua Li Jessica Liu Mark Mansour Esther Masih-Khan Tong Zhang Scott V. Bratman Amit M. Oza Suzanne Kamel-Reid Suzanne Trudel Trevor J. Pugh
author_sort	Olena Kis
title	Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
title_short	Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
title_full	Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
title_fullStr	Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
title_full_unstemmed	Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
title_sort	circulating tumour dna sequence analysis as an alternative to multiple myeloma bone marrow aspirates
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d52e507d56a94e48a45f62b403d8d6ed
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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates

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