The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases

Neurodegenerative diseases (NDs) belong to the top global causes of mortality. Diagnostic approaches to improve early diagnosis and differentiation of these diseases are constantly being sought. Therefore, we aimed to assess the cerebrospinal fluid (CSF) concentrations of Reticulon 4 (RTN4) in patie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Agnieszka Kulczyńska-Przybik, Maciej Dulewicz, Agnieszka Słowik, Renata Borawska, Alina Kułakowska, Jan Kochanowicz, Barbara Mroczko
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	RTN-4A reticulons biomarkers Alzheimer’s disease Parkinson’s disease multiple sclerosis Medicine R
Acceso en línea:	https://doaj.org/article/d52f043bcdfc40b9ac39ec16e5b669b8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d52f043bcdfc40b9ac39ec16e5b669b8
record_format	dspace
spelling	oai:doaj.org-article:d52f043bcdfc40b9ac39ec16e5b669b82021-11-25T18:01:20ZThe Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases10.3390/jcm102252812077-0383https://doaj.org/article/d52f043bcdfc40b9ac39ec16e5b669b82021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5281https://doaj.org/toc/2077-0383Neurodegenerative diseases (NDs) belong to the top global causes of mortality. Diagnostic approaches to improve early diagnosis and differentiation of these diseases are constantly being sought. Therefore, we aimed to assess the cerebrospinal fluid (CSF) concentrations of Reticulon 4 (RTN4) in patients with neurodegenerative diseases and evaluate the potential clinical usefulness of this protein. RTNs are transmembrane proteins mediating neuroanatomical plasticity and functional recovery after central nervous system injury or diseases. According to our best knowledge, this is the first investigation providing the data concerning the dynamic of CSF RTN4 protein levels in patients with different NDs. Methods: Overall, 77 newly diagnosed patients with neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS), as well as 21 controls, were enrolled in the study. The CSF concentrations of tested proteins were assessed using immunological assays. Results: We revealed significantly higher CSF RTN4A levels in patients with AD, PD, and MS in comparison to the controls. Moreover, the comparative analysis of RTN4 concentration between different neurodegenerative diseases revealed the highest concentration of RTN4A in AD patients and a statistically significant difference between AD vs. PD, and AD vs. MS groups. The increased CSF level of the protein correlated with Tau, and pTau181 proteins in AD as well as in PD patients. Conclusions: Our study presents a previously not identified clinical utility of RTN4 in the differential diagnosis of neurodegenerative diseases.Agnieszka Kulczyńska-PrzybikMaciej DulewiczAgnieszka SłowikRenata BorawskaAlina KułakowskaJan KochanowiczBarbara MroczkoMDPI AGarticleRTN-4AreticulonsbiomarkersAlzheimer’s diseaseParkinson’s diseasemultiple sclerosisMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5281, p 5281 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RTN-4A reticulons biomarkers Alzheimer’s disease Parkinson’s disease multiple sclerosis Medicine R
spellingShingle	RTN-4A reticulons biomarkers Alzheimer’s disease Parkinson’s disease multiple sclerosis Medicine R Agnieszka Kulczyńska-Przybik Maciej Dulewicz Agnieszka Słowik Renata Borawska Alina Kułakowska Jan Kochanowicz Barbara Mroczko The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases
description	Neurodegenerative diseases (NDs) belong to the top global causes of mortality. Diagnostic approaches to improve early diagnosis and differentiation of these diseases are constantly being sought. Therefore, we aimed to assess the cerebrospinal fluid (CSF) concentrations of Reticulon 4 (RTN4) in patients with neurodegenerative diseases and evaluate the potential clinical usefulness of this protein. RTNs are transmembrane proteins mediating neuroanatomical plasticity and functional recovery after central nervous system injury or diseases. According to our best knowledge, this is the first investigation providing the data concerning the dynamic of CSF RTN4 protein levels in patients with different NDs. Methods: Overall, 77 newly diagnosed patients with neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS), as well as 21 controls, were enrolled in the study. The CSF concentrations of tested proteins were assessed using immunological assays. Results: We revealed significantly higher CSF RTN4A levels in patients with AD, PD, and MS in comparison to the controls. Moreover, the comparative analysis of RTN4 concentration between different neurodegenerative diseases revealed the highest concentration of RTN4A in AD patients and a statistically significant difference between AD vs. PD, and AD vs. MS groups. The increased CSF level of the protein correlated with Tau, and pTau181 proteins in AD as well as in PD patients. Conclusions: Our study presents a previously not identified clinical utility of RTN4 in the differential diagnosis of neurodegenerative diseases.
format	article
author	Agnieszka Kulczyńska-Przybik Maciej Dulewicz Agnieszka Słowik Renata Borawska Alina Kułakowska Jan Kochanowicz Barbara Mroczko
author_facet	Agnieszka Kulczyńska-Przybik Maciej Dulewicz Agnieszka Słowik Renata Borawska Alina Kułakowska Jan Kochanowicz Barbara Mroczko
author_sort	Agnieszka Kulczyńska-Przybik
title	The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases
title_short	The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases
title_full	The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases
title_fullStr	The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases
title_full_unstemmed	The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases
title_sort	clinical significance of cerebrospinal fluid reticulon 4 (rtn4) levels in the differential diagnosis of neurodegenerative diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d52f043bcdfc40b9ac39ec16e5b669b8
work_keys_str_mv	AT agnieszkakulczynskaprzybik theclinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT maciejdulewicz theclinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT agnieszkasłowik theclinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT renataborawska theclinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT alinakułakowska theclinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT jankochanowicz theclinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT barbaramroczko theclinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT agnieszkakulczynskaprzybik clinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT maciejdulewicz clinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT agnieszkasłowik clinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT renataborawska clinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT alinakułakowska clinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT jankochanowicz clinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases AT barbaramroczko clinicalsignificanceofcerebrospinalfluidreticulon4rtn4levelsinthedifferentialdiagnosisofneurodegenerativediseases
_version_	1718411771032633344

The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases

Ejemplares similares