Association of body mass index with mortality and functional outcome after acute ischemic stroke

Abstract The relation between obesity and stroke outcome has been disputed. This study was aimed to determine the association of body mass index (BMI) with mortality and functional outcome in patients with acute ischemic stroke. Data were from a national, multi-centre, prospective, hospital-based re...

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Autores principales:	Weiping Sun, Yining Huang, Ying Xian, Sainan Zhu, Zhirong Jia, Ran Liu, Fan Li, Jade W. Wei, Ji-Guang Wang, Ming Liu, Craig S. Anderson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d530b4782cc14668bcede37f8ad332bb
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spelling	oai:doaj.org-article:d530b4782cc14668bcede37f8ad332bb2021-12-02T16:07:47ZAssociation of body mass index with mortality and functional outcome after acute ischemic stroke10.1038/s41598-017-02551-02045-2322https://doaj.org/article/d530b4782cc14668bcede37f8ad332bb2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02551-0https://doaj.org/toc/2045-2322Abstract The relation between obesity and stroke outcome has been disputed. This study was aimed to determine the association of body mass index (BMI) with mortality and functional outcome in patients with acute ischemic stroke. Data were from a national, multi-centre, prospective, hospital-based register: the ChinaQUEST (Quality Evaluation of Stroke Care and Treatment) study. Of 4782 acute ischemic stroke patients, 282 were underweight (BMI < 18.5 kg/m2), 2306 were normal-weight (BMI 18.5 to < 24 kg/m2), 1677 were overweight (BMI 24 to <28 kg/m2) and 517 were obese (BMI ≥ 28 kg/m2). The risks of death at 12 months and death or high dependency at 3 and 12 months in overweight (HR: 0.97, 95% CI: 0.78–1.20; OR: 0.93, 95% CI: 0.80–1.09; OR: 0.95, 95% CI: 0.81–1.12) and obese patients (HR: 1.07, 95% CI: 0.78–1.48; OR: 0.96, 95% CI: 0.75–1.22; OR: 1.06, 95% CI: 0.83–1.35) did not differ from normal-weight patients significantly after adjusting for baseline characteristics. Underweight patients had significantly increased risks of these three outcomes. In ischemic stroke patients, being overweight or obese was not associated with decreased mortality or better functional recovery but being underweight predicted unfavourable outcomes.Weiping SunYining HuangYing XianSainan ZhuZhirong JiaRan LiuFan LiJade W. WeiJi-Guang WangMing LiuCraig S. AndersonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weiping Sun Yining Huang Ying Xian Sainan Zhu Zhirong Jia Ran Liu Fan Li Jade W. Wei Ji-Guang Wang Ming Liu Craig S. Anderson Association of body mass index with mortality and functional outcome after acute ischemic stroke
description	Abstract The relation between obesity and stroke outcome has been disputed. This study was aimed to determine the association of body mass index (BMI) with mortality and functional outcome in patients with acute ischemic stroke. Data were from a national, multi-centre, prospective, hospital-based register: the ChinaQUEST (Quality Evaluation of Stroke Care and Treatment) study. Of 4782 acute ischemic stroke patients, 282 were underweight (BMI < 18.5 kg/m2), 2306 were normal-weight (BMI 18.5 to < 24 kg/m2), 1677 were overweight (BMI 24 to <28 kg/m2) and 517 were obese (BMI ≥ 28 kg/m2). The risks of death at 12 months and death or high dependency at 3 and 12 months in overweight (HR: 0.97, 95% CI: 0.78–1.20; OR: 0.93, 95% CI: 0.80–1.09; OR: 0.95, 95% CI: 0.81–1.12) and obese patients (HR: 1.07, 95% CI: 0.78–1.48; OR: 0.96, 95% CI: 0.75–1.22; OR: 1.06, 95% CI: 0.83–1.35) did not differ from normal-weight patients significantly after adjusting for baseline characteristics. Underweight patients had significantly increased risks of these three outcomes. In ischemic stroke patients, being overweight or obese was not associated with decreased mortality or better functional recovery but being underweight predicted unfavourable outcomes.
format	article
author	Weiping Sun Yining Huang Ying Xian Sainan Zhu Zhirong Jia Ran Liu Fan Li Jade W. Wei Ji-Guang Wang Ming Liu Craig S. Anderson
author_facet	Weiping Sun Yining Huang Ying Xian Sainan Zhu Zhirong Jia Ran Liu Fan Li Jade W. Wei Ji-Guang Wang Ming Liu Craig S. Anderson
author_sort	Weiping Sun
title	Association of body mass index with mortality and functional outcome after acute ischemic stroke
title_short	Association of body mass index with mortality and functional outcome after acute ischemic stroke
title_full	Association of body mass index with mortality and functional outcome after acute ischemic stroke
title_fullStr	Association of body mass index with mortality and functional outcome after acute ischemic stroke
title_full_unstemmed	Association of body mass index with mortality and functional outcome after acute ischemic stroke
title_sort	association of body mass index with mortality and functional outcome after acute ischemic stroke
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d530b4782cc14668bcede37f8ad332bb
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_version_	1718384748227723264

Association of body mass index with mortality and functional outcome after acute ischemic stroke

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