Impact of persistent D-dimer elevation following recovery from COVID-19.

<h4>Background</h4>Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic complications, but it is also a direct consequence of the acute lung injury seen in COVID-19 pneumonia.<h4>Objectives</h4>To eval...

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Autores principales:	Antje Lehmann, Helmut Prosch, Sonja Zehetmayer, Maximilian Robert Gysan, Dominik Bernitzky, Karin Vonbank, Marco Idzko, Daniela Gompelmann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d53ce351dd554a879170749359adbe49
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spelling	oai:doaj.org-article:d53ce351dd554a879170749359adbe492021-12-02T20:13:25ZImpact of persistent D-dimer elevation following recovery from COVID-19.1932-620310.1371/journal.pone.0258351https://doaj.org/article/d53ce351dd554a879170749359adbe492021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258351https://doaj.org/toc/1932-6203<h4>Background</h4>Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic complications, but it is also a direct consequence of the acute lung injury seen in COVID-19 pneumonia.<h4>Objectives</h4>To evaluate the rate of persistent elevated D-dimer and its association with thromboembolic complications and persistent ground glass opacities (GGO) after recovery from COVID-19.<h4>Methods</h4>In this post hoc analysis of a prospective multicenter trial, patients underwent blood sampling, measurement of diffusion capacity, blood gas analysis, and multidetector computed tomography (MDCT) scan following COVID-19. In case of increased D-dimer (>0,5 μg/ml), an additional contrast medium-enhanced CT was performed in absence of contraindications. Results were compared between patients with persistent D-dimer elevation and patients with normal D-dimer level.<h4>Results</h4>129 patients (median age 48.8 years; range 19-91 years) underwent D-Dimer assessment after a median (IQR) of 94 days (64-130) following COVID-19. D-dimer elevation was found in 15% (19/129) and was significantly more common in patients who had experienced a severe SARS-CoV2 infection that had required hospitalisation compared to patients with mild disease (p = 0.049). Contrast-medium CT (n = 15) revealed an acute pulmonary embolism in one patient and CTEPH in another patient. A significant lower mean pO2 (p = 0.015) and AaDO2 (p = 0.043) were observed in patients with persistent D-Dimer elevation, but the rate of GGO were similar in both patient groups (p = 0.33).<h4>Conclusion</h4>In 15% of the patients recovered from COVID-19, persistent D-dimer elevation was observed after a median of 3 months following COVID-19. These patients had experienced a more severe COVID and still presented more frequently a lower mean pO2 and AaDO2.Antje LehmannHelmut ProschSonja ZehetmayerMaximilian Robert GysanDominik BernitzkyKarin VonbankMarco IdzkoDaniela GompelmannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258351 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antje Lehmann Helmut Prosch Sonja Zehetmayer Maximilian Robert Gysan Dominik Bernitzky Karin Vonbank Marco Idzko Daniela Gompelmann Impact of persistent D-dimer elevation following recovery from COVID-19.
description	<h4>Background</h4>Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic complications, but it is also a direct consequence of the acute lung injury seen in COVID-19 pneumonia.<h4>Objectives</h4>To evaluate the rate of persistent elevated D-dimer and its association with thromboembolic complications and persistent ground glass opacities (GGO) after recovery from COVID-19.<h4>Methods</h4>In this post hoc analysis of a prospective multicenter trial, patients underwent blood sampling, measurement of diffusion capacity, blood gas analysis, and multidetector computed tomography (MDCT) scan following COVID-19. In case of increased D-dimer (>0,5 μg/ml), an additional contrast medium-enhanced CT was performed in absence of contraindications. Results were compared between patients with persistent D-dimer elevation and patients with normal D-dimer level.<h4>Results</h4>129 patients (median age 48.8 years; range 19-91 years) underwent D-Dimer assessment after a median (IQR) of 94 days (64-130) following COVID-19. D-dimer elevation was found in 15% (19/129) and was significantly more common in patients who had experienced a severe SARS-CoV2 infection that had required hospitalisation compared to patients with mild disease (p = 0.049). Contrast-medium CT (n = 15) revealed an acute pulmonary embolism in one patient and CTEPH in another patient. A significant lower mean pO2 (p = 0.015) and AaDO2 (p = 0.043) were observed in patients with persistent D-Dimer elevation, but the rate of GGO were similar in both patient groups (p = 0.33).<h4>Conclusion</h4>In 15% of the patients recovered from COVID-19, persistent D-dimer elevation was observed after a median of 3 months following COVID-19. These patients had experienced a more severe COVID and still presented more frequently a lower mean pO2 and AaDO2.
format	article
author	Antje Lehmann Helmut Prosch Sonja Zehetmayer Maximilian Robert Gysan Dominik Bernitzky Karin Vonbank Marco Idzko Daniela Gompelmann
author_facet	Antje Lehmann Helmut Prosch Sonja Zehetmayer Maximilian Robert Gysan Dominik Bernitzky Karin Vonbank Marco Idzko Daniela Gompelmann
author_sort	Antje Lehmann
title	Impact of persistent D-dimer elevation following recovery from COVID-19.
title_short	Impact of persistent D-dimer elevation following recovery from COVID-19.
title_full	Impact of persistent D-dimer elevation following recovery from COVID-19.
title_fullStr	Impact of persistent D-dimer elevation following recovery from COVID-19.
title_full_unstemmed	Impact of persistent D-dimer elevation following recovery from COVID-19.
title_sort	impact of persistent d-dimer elevation following recovery from covid-19.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d53ce351dd554a879170749359adbe49
work_keys_str_mv	AT antjelehmann impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT helmutprosch impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT sonjazehetmayer impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT maximilianrobertgysan impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT dominikbernitzky impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT karinvonbank impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT marcoidzko impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT danielagompelmann impactofpersistentddimerelevationfollowingrecoveryfromcovid19
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Impact of persistent D-dimer elevation following recovery from COVID-19.

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