Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor

Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor

Single-cell whole-exome sequencing is a powerful method for deciphering intratumor heterogeneity and identifying cancer drivers. Here, the authors analyze SNVs and CNVs simultaneously in bulk and single cells of BRCA1-associated breast tissues and cancers and show that Plekha5 deficiency promotes me...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jianlin Liu, Ragini Adhav, Kai Miao, Sek Man Su, Lihua Mo, Un In Chan, Xin Zhang, Jun Xu, Jianjie Li, Xiaodong Shu, Jianming Zeng, Xu Zhang, Xueying Lyu, Lakhansing Pardeshi, Kaeling Tan, Heng Sun, Koon Ho Wong, Chuxia Deng, Xiaoling Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d53cfce3edcf43e990fb6d21a06b3a89
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Single-cell whole-exome sequencing is a powerful method for deciphering intratumor heterogeneity and identifying cancer drivers. Here, the authors analyze SNVs and CNVs simultaneously in bulk and single cells of BRCA1-associated breast tissues and cancers and show that Plekha5 deficiency promotes metastasis.

Ejemplares similares