Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.

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Autores principales: Wenqing Ren, Nicole Medeiros, Robert Warneford-Thomson, Phillip Wulfridge, Qingqing Yan, Joyce Bian, Simone Sidoli, Benjamin A. Garcia, Emmanuel Skordalakes, Eric Joyce, Roberto Bonasio, Kavitha Sarma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d53e091c9d8f44fbb7268b39edf59f2b
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spelling oai:doaj.org-article:d53e091c9d8f44fbb7268b39edf59f2b2021-12-02T14:42:28ZDisruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function10.1038/s41467-020-15902-92041-1723https://doaj.org/article/d53e091c9d8f44fbb7268b39edf59f2b2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15902-9https://doaj.org/toc/2041-1723ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.Wenqing RenNicole MedeirosRobert Warneford-ThomsonPhillip WulfridgeQingqing YanJoyce BianSimone SidoliBenjamin A. GarciaEmmanuel SkordalakesEric JoyceRoberto BonasioKavitha SarmaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wenqing Ren
Nicole Medeiros
Robert Warneford-Thomson
Phillip Wulfridge
Qingqing Yan
Joyce Bian
Simone Sidoli
Benjamin A. Garcia
Emmanuel Skordalakes
Eric Joyce
Roberto Bonasio
Kavitha Sarma
Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
description ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.
format article
author Wenqing Ren
Nicole Medeiros
Robert Warneford-Thomson
Phillip Wulfridge
Qingqing Yan
Joyce Bian
Simone Sidoli
Benjamin A. Garcia
Emmanuel Skordalakes
Eric Joyce
Roberto Bonasio
Kavitha Sarma
author_facet Wenqing Ren
Nicole Medeiros
Robert Warneford-Thomson
Phillip Wulfridge
Qingqing Yan
Joyce Bian
Simone Sidoli
Benjamin A. Garcia
Emmanuel Skordalakes
Eric Joyce
Roberto Bonasio
Kavitha Sarma
author_sort Wenqing Ren
title Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
title_short Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
title_full Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
title_fullStr Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
title_full_unstemmed Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
title_sort disruption of atrx-rna interactions uncovers roles in atrx localization and prc2 function
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d53e091c9d8f44fbb7268b39edf59f2b
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