Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.

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Auteurs principaux:	Wenqing Ren, Nicole Medeiros, Robert Warneford-Thomson, Phillip Wulfridge, Qingqing Yan, Joyce Bian, Simone Sidoli, Benjamin A. Garcia, Emmanuel Skordalakes, Eric Joyce, Roberto Bonasio, Kavitha Sarma
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/d53e091c9d8f44fbb7268b39edf59f2b
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spelling	oai:doaj.org-article:d53e091c9d8f44fbb7268b39edf59f2b2021-12-02T14:42:28ZDisruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function10.1038/s41467-020-15902-92041-1723https://doaj.org/article/d53e091c9d8f44fbb7268b39edf59f2b2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15902-9https://doaj.org/toc/2041-1723ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.Wenqing RenNicole MedeirosRobert Warneford-ThomsonPhillip WulfridgeQingqing YanJoyce BianSimone SidoliBenjamin A. GarciaEmmanuel SkordalakesEric JoyceRoberto BonasioKavitha SarmaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenqing Ren Nicole Medeiros Robert Warneford-Thomson Phillip Wulfridge Qingqing Yan Joyce Bian Simone Sidoli Benjamin A. Garcia Emmanuel Skordalakes Eric Joyce Roberto Bonasio Kavitha Sarma Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
description	ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.
format	article
author	Wenqing Ren Nicole Medeiros Robert Warneford-Thomson Phillip Wulfridge Qingqing Yan Joyce Bian Simone Sidoli Benjamin A. Garcia Emmanuel Skordalakes Eric Joyce Roberto Bonasio Kavitha Sarma
author_facet	Wenqing Ren Nicole Medeiros Robert Warneford-Thomson Phillip Wulfridge Qingqing Yan Joyce Bian Simone Sidoli Benjamin A. Garcia Emmanuel Skordalakes Eric Joyce Roberto Bonasio Kavitha Sarma
author_sort	Wenqing Ren
title	Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
title_short	Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
title_full	Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
title_fullStr	Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
title_full_unstemmed	Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
title_sort	disruption of atrx-rna interactions uncovers roles in atrx localization and prc2 function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d53e091c9d8f44fbb7268b39edf59f2b
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Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

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