Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Dysregulation of glutamate transporters has been a common finding across animal models of epilepsy and in patients with TLE. In this study, we investigate NRG-1/ErbB4 signaling in epileptogenesis and the neuroprotective effects...

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Autores principales:	Allison R. Peterson, Terese A. Garcia, Byron D. Ford, Devin K. Binder
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Neuregulin-1 Epilepsy ErbB4 Neuroprotection EAAC1 Glutamate synthetase Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/d53f9bcbd4964555aaf902fb4e298b84
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spelling	oai:doaj.org-article:d53f9bcbd4964555aaf902fb4e298b842021-12-04T04:33:11ZRegulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy1095-953X10.1016/j.nbd.2021.105545https://doaj.org/article/d53f9bcbd4964555aaf902fb4e298b842021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0969996121002941https://doaj.org/toc/1095-953XTemporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Dysregulation of glutamate transporters has been a common finding across animal models of epilepsy and in patients with TLE. In this study, we investigate NRG-1/ErbB4 signaling in epileptogenesis and the neuroprotective effects of NRG-1 treatment in a mouse model of temporal lobe epilepsy. Using immunohistochemistry, we report the first evidence for NRG-1/ErbB4-dependent selective upregulation of glutamate transporter EAAC1 and bihemispheric neuroprotection by exogeneous NRG-1 in the intrahippocampal kainic acid (IHKA) model of TLE. Our findings provide evidence that dysregulation of glutamate transporter EAAC1 contributes to the development of epilepsy and can be therapeutically targeted to reduce neuronal death following IHKA-induced status epilepticus (SE).Allison R. PetersonTerese A. GarciaByron D. FordDevin K. BinderElsevierarticleNeuregulin-1EpilepsyErbB4NeuroprotectionEAAC1Glutamate synthetaseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeurobiology of Disease, Vol 161, Iss , Pp 105545- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neuregulin-1 Epilepsy ErbB4 Neuroprotection EAAC1 Glutamate synthetase Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neuregulin-1 Epilepsy ErbB4 Neuroprotection EAAC1 Glutamate synthetase Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Allison R. Peterson Terese A. Garcia Byron D. Ford Devin K. Binder Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy
description	Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Dysregulation of glutamate transporters has been a common finding across animal models of epilepsy and in patients with TLE. In this study, we investigate NRG-1/ErbB4 signaling in epileptogenesis and the neuroprotective effects of NRG-1 treatment in a mouse model of temporal lobe epilepsy. Using immunohistochemistry, we report the first evidence for NRG-1/ErbB4-dependent selective upregulation of glutamate transporter EAAC1 and bihemispheric neuroprotection by exogeneous NRG-1 in the intrahippocampal kainic acid (IHKA) model of TLE. Our findings provide evidence that dysregulation of glutamate transporter EAAC1 contributes to the development of epilepsy and can be therapeutically targeted to reduce neuronal death following IHKA-induced status epilepticus (SE).
format	article
author	Allison R. Peterson Terese A. Garcia Byron D. Ford Devin K. Binder
author_facet	Allison R. Peterson Terese A. Garcia Byron D. Ford Devin K. Binder
author_sort	Allison R. Peterson
title	Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy
title_short	Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy
title_full	Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy
title_fullStr	Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy
title_full_unstemmed	Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy
title_sort	regulation of nrg-1-erbb4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d53f9bcbd4964555aaf902fb4e298b84
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Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy

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