Choroidal thickness changes in systemic lupus erythematosus patients

Arnaldo Dias-Santos,1–3 Joana Tavares Ferreira,1–3 Sofia Pinheiro,4 João Paulo Cunha,1,3 Marta Alves,5 Ana Luísa Papoila,3,5–6 Maria Francisca Moraes-Fontes,3,7–8 Rui Proença9,101Department of Ophthalmology, Centro Hospitalar e...

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Autores principales:	Dias-Santos A, Tavares Ferreira J, Pinheiro S, Cunha JP, Alves M, Papoila AL, Moraes-Fontes MF, Proença R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	choroidal thickness enhanced depth imaging spectral domain optical coherence tomography systemic lupus erythematosus Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d5420dbed5324366b9de4e5900eb4a9e
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spelling	oai:doaj.org-article:d5420dbed5324366b9de4e5900eb4a9e2021-12-02T08:11:00ZChoroidal thickness changes in systemic lupus erythematosus patients1177-5483https://doaj.org/article/d5420dbed5324366b9de4e5900eb4a9e2019-08-01T00:00:00Zhttps://www.dovepress.com/choroidal-thickness-changes-in-systemic-lupus-erythematosus-patients-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Arnaldo Dias-Santos,1–3 Joana Tavares Ferreira,1–3 Sofia Pinheiro,4 João Paulo Cunha,1,3 Marta Alves,5 Ana Luísa Papoila,3,5–6 Maria Francisca Moraes-Fontes,3,7–8 Rui Proença9,101Department of Ophthalmology, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal; 2Department of Ophthalmology, Hospital CUF Descobertas, Lisbon, Portugal; 3NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal; 4Autoimmune Disease Unit, Unidade de Doenças Auto-imunes/serviço Medicina 3, Hospital de Santo António Dos Capuchos, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal; 5Epidemiology and Statistics Unit, Research Center, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal; 6CEAUL (Center of Statistics and Applications), Lisbon University, Lisbon, Portugal; 7Autoimmune Disease Unit, Unidade de Doenças Auto-imunes/serviço de Medicina 7.2, Hospital Curry Cabral, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal; 8Instituto Gulbenkian de Ciência, Oeiras, Portugal; 9Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 10Faculty of Medicine, University of Coimbra, Coimbra, PortugalCorrespondence: Arnaldo Dias-SantosServiço de Oftalmologia, Hospital de Santo António dos Capuchos, Alameda de Santo António dos Capuchos, Lisboa 1169-050, PortugalTel +351 21313 6492Email arnaldomiguelsantos@gmail.comPurpose: To compare choroidal thickness (CT) between patients with systemic lupus erythematosus (SLE) without ophthalmologic manifestations and a control group. To study the effects in CT of disease duration, activity index, medication and systemic comorbidities.Methods: Cross-sectional study where spectral-domain optical coherence tomography with enhanced depth imaging was used to measure CT in 13 locations, subfoveally and at 500-μm intervals along a horizontal and a vertical section from the fovea. Linear regression models were used.Results: Sixty-eight SLE patients and fifty healthy controls were enrolled. CT multivariable analysis revealed lower values in SLE patients (12.93–26.73 μm thinner) in all locations, except the inferior quadrants (6.48–10.44 μm thicker); however, none of these results reached statistical significance. Contrary to the control group, the normal topographic variation in CT between macular quadrants and from the center to the periphery was not observed in the SLE group. Multivariable analysis in the SLE group alone revealed a significant negative association with anticoagulants (50.10–56.09 μm thinner) and lupus nephritis (40.79–58.63 μm thinner). Contrary to controls, the CT of SLE patients did not respond to changes in mean arterial pressure.Conclusion: CT in SLE appears to be thinner, particularly in the subset of patients with nephritis and taking anticoagulants, suggesting more advanced systemic vascular disease. Choroidal responses to hemodynamic changes may also be altered in SLE.Keywords: choroidal thickness, enhanced depth imaging, spectral domain optical coherence tomography, systemic lupus erythematosusDias-Santos ATavares Ferreira JPinheiro SCunha JPAlves MPapoila ALMoraes-Fontes MFProença RDove Medical Pressarticlechoroidal thicknessenhanced depth imagingspectral domain optical coherence tomographysystemic lupus erythematosusOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1567-1578 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	choroidal thickness enhanced depth imaging spectral domain optical coherence tomography systemic lupus erythematosus Ophthalmology RE1-994
spellingShingle	choroidal thickness enhanced depth imaging spectral domain optical coherence tomography systemic lupus erythematosus Ophthalmology RE1-994 Dias-Santos A Tavares Ferreira J Pinheiro S Cunha JP Alves M Papoila AL Moraes-Fontes MF Proença R Choroidal thickness changes in systemic lupus erythematosus patients
description	Arnaldo Dias-Santos,1–3 Joana Tavares Ferreira,1–3 Sofia Pinheiro,4 João Paulo Cunha,1,3 Marta Alves,5 Ana Luísa Papoila,3,5–6 Maria Francisca Moraes-Fontes,3,7–8 Rui Proença9,101Department of Ophthalmology, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal; 2Department of Ophthalmology, Hospital CUF Descobertas, Lisbon, Portugal; 3NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal; 4Autoimmune Disease Unit, Unidade de Doenças Auto-imunes/serviço Medicina 3, Hospital de Santo António Dos Capuchos, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal; 5Epidemiology and Statistics Unit, Research Center, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal; 6CEAUL (Center of Statistics and Applications), Lisbon University, Lisbon, Portugal; 7Autoimmune Disease Unit, Unidade de Doenças Auto-imunes/serviço de Medicina 7.2, Hospital Curry Cabral, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal; 8Instituto Gulbenkian de Ciência, Oeiras, Portugal; 9Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 10Faculty of Medicine, University of Coimbra, Coimbra, PortugalCorrespondence: Arnaldo Dias-SantosServiço de Oftalmologia, Hospital de Santo António dos Capuchos, Alameda de Santo António dos Capuchos, Lisboa 1169-050, PortugalTel +351 21313 6492Email arnaldomiguelsantos@gmail.comPurpose: To compare choroidal thickness (CT) between patients with systemic lupus erythematosus (SLE) without ophthalmologic manifestations and a control group. To study the effects in CT of disease duration, activity index, medication and systemic comorbidities.Methods: Cross-sectional study where spectral-domain optical coherence tomography with enhanced depth imaging was used to measure CT in 13 locations, subfoveally and at 500-μm intervals along a horizontal and a vertical section from the fovea. Linear regression models were used.Results: Sixty-eight SLE patients and fifty healthy controls were enrolled. CT multivariable analysis revealed lower values in SLE patients (12.93–26.73 μm thinner) in all locations, except the inferior quadrants (6.48–10.44 μm thicker); however, none of these results reached statistical significance. Contrary to the control group, the normal topographic variation in CT between macular quadrants and from the center to the periphery was not observed in the SLE group. Multivariable analysis in the SLE group alone revealed a significant negative association with anticoagulants (50.10–56.09 μm thinner) and lupus nephritis (40.79–58.63 μm thinner). Contrary to controls, the CT of SLE patients did not respond to changes in mean arterial pressure.Conclusion: CT in SLE appears to be thinner, particularly in the subset of patients with nephritis and taking anticoagulants, suggesting more advanced systemic vascular disease. Choroidal responses to hemodynamic changes may also be altered in SLE.Keywords: choroidal thickness, enhanced depth imaging, spectral domain optical coherence tomography, systemic lupus erythematosus
format	article
author	Dias-Santos A Tavares Ferreira J Pinheiro S Cunha JP Alves M Papoila AL Moraes-Fontes MF Proença R
author_facet	Dias-Santos A Tavares Ferreira J Pinheiro S Cunha JP Alves M Papoila AL Moraes-Fontes MF Proença R
author_sort	Dias-Santos A
title	Choroidal thickness changes in systemic lupus erythematosus patients
title_short	Choroidal thickness changes in systemic lupus erythematosus patients
title_full	Choroidal thickness changes in systemic lupus erythematosus patients
title_fullStr	Choroidal thickness changes in systemic lupus erythematosus patients
title_full_unstemmed	Choroidal thickness changes in systemic lupus erythematosus patients
title_sort	choroidal thickness changes in systemic lupus erythematosus patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/d5420dbed5324366b9de4e5900eb4a9e
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Choroidal thickness changes in systemic lupus erythematosus patients

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