Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell respon...

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Autores principales:	Giulia Escobar, Luigi Barbarossa, Giulia Barbiera, Margherita Norelli, Marco Genua, Anna Ranghetti, Tiziana Plati, Barbara Camisa, Chiara Brombin, Davide Cittaro, Andrea Annoni, Attilio Bondanza, Renato Ostuni, Bernhard Gentner, Luigi Naldini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d5447487f0d9463493bef78ed95681ca
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spelling	oai:doaj.org-article:d5447487f0d9463493bef78ed95681ca2021-12-02T14:38:51ZInterferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens10.1038/s41467-018-05315-02041-1723https://doaj.org/article/d5447487f0d9463493bef78ed95681ca2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05315-0https://doaj.org/toc/2041-1723An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses.Giulia EscobarLuigi BarbarossaGiulia BarbieraMargherita NorelliMarco GenuaAnna RanghettiTiziana PlatiBarbara CamisaChiara BrombinDavide CittaroAndrea AnnoniAttilio BondanzaRenato OstuniBernhard GentnerLuigi NaldiniNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giulia Escobar Luigi Barbarossa Giulia Barbiera Margherita Norelli Marco Genua Anna Ranghetti Tiziana Plati Barbara Camisa Chiara Brombin Davide Cittaro Andrea Annoni Attilio Bondanza Renato Ostuni Bernhard Gentner Luigi Naldini Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
description	An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses.
format	article
author	Giulia Escobar Luigi Barbarossa Giulia Barbiera Margherita Norelli Marco Genua Anna Ranghetti Tiziana Plati Barbara Camisa Chiara Brombin Davide Cittaro Andrea Annoni Attilio Bondanza Renato Ostuni Bernhard Gentner Luigi Naldini
author_facet	Giulia Escobar Luigi Barbarossa Giulia Barbiera Margherita Norelli Marco Genua Anna Ranghetti Tiziana Plati Barbara Camisa Chiara Brombin Davide Cittaro Andrea Annoni Attilio Bondanza Renato Ostuni Bernhard Gentner Luigi Naldini
author_sort	Giulia Escobar
title	Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
title_short	Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
title_full	Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
title_fullStr	Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
title_full_unstemmed	Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
title_sort	interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d5447487f0d9463493bef78ed95681ca
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Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

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