An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach

Herbal remedies have been used in many cultures for decades to treat illnesses. These medicinal plants have been found to contain various phytochemical compounds that can help to cure mild to severe illnesses. The inadequacies of conventional medicines and their unusual side effects sparked a determ...

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Autores principales:	Md. Rafat Tahsin, Arifa Sultana, Muhammad Shah Mohtasim Khan, Ishrat Jahan, Sabiha Rahman Mim, Tanzia Islam Tithi, Mokaddas Flora Ananta, Sadia Afrin, Mehnaz Ali, M. Sajjad Hussain, Jakir Ahmed Chowdhury, Shaila Kabir, Abu Asad Chowdhury, Md. Shah Amran, Fahima Aktar
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Herbal remedy Anti-depressant Anti-diabetic Analgesic In-silico study T.arjuna Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/d547bb7ba18446fabccb061ca0819a82
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spelling	oai:doaj.org-article:d547bb7ba18446fabccb061ca0819a822021-12-02T05:02:14ZAn evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach2405-844010.1016/j.heliyon.2021.e08225https://doaj.org/article/d547bb7ba18446fabccb061ca0819a822021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021023288https://doaj.org/toc/2405-8440Herbal remedies have been used in many cultures for decades to treat illnesses. These medicinal plants have been found to contain various phytochemical compounds that can help to cure mild to severe illnesses. The inadequacies of conventional medicines and their unusual side effects sparked a determined search for alternative natural therapeutic agents. Another reason for this hunt could be the availability and fewer side effects of natural products. T. arjuna is widely used in traditional medicine to alleviate various diseases like relieving pain, ameliorating diabetes, mitigating inflammation, and back-pedaling of depression. In this study, the ethanolic extract of T. arjuna possesses a promising effect on the animal model (p < 0.05/p < 0.01) as an antihyperglycemic, analgesic, anti-inflammatory, and antidepressant agent, but in a dose-dependent manner. The lower dose of T. arjuna was found to be capable of reversing the disturbed physiological state at a significant level (p < 0.05). However, a higher dose of T. arjuna exerts better therapeutic effects for those diseases. This animal study aims to evaluate the anti-diabetic, anti-depressant, and anti-inflammatory properties of T. arjuna compared to conventional marketed drugs. We will perform an in-silico study for active constituents of T. arjuna against their proposed targets and look for the molecular cascade on their claimed pharmacological properties. This study shows that different doses of T. arjuna bark extracts give similar therapeutic responses compared with established marketed drugs in managing hyperglycemia, stress-induced depression, and inflammation. Besides, our docking study reveals that flavonoids and triterpenoid active constituents of T. arjuna play an important role in its usefulness. This study, therefore, scientifically confirmed the traditional use of this medicinal plant in the management of several diseased conditions.Md. Rafat TahsinArifa SultanaMuhammad Shah Mohtasim KhanIshrat JahanSabiha Rahman MimTanzia Islam TithiMokaddas Flora AnantaSadia AfrinMehnaz AliM. Sajjad HussainJakir Ahmed ChowdhuryShaila KabirAbu Asad ChowdhuryMd. Shah AmranFahima AktarElsevierarticleHerbal remedyAnti-depressantAnti-diabeticAnalgesicIn-silico studyT.arjunaScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08225- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Herbal remedy Anti-depressant Anti-diabetic Analgesic In-silico study T.arjuna Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Herbal remedy Anti-depressant Anti-diabetic Analgesic In-silico study T.arjuna Science (General) Q1-390 Social sciences (General) H1-99 Md. Rafat Tahsin Arifa Sultana Muhammad Shah Mohtasim Khan Ishrat Jahan Sabiha Rahman Mim Tanzia Islam Tithi Mokaddas Flora Ananta Sadia Afrin Mehnaz Ali M. Sajjad Hussain Jakir Ahmed Chowdhury Shaila Kabir Abu Asad Chowdhury Md. Shah Amran Fahima Aktar An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach
description	Herbal remedies have been used in many cultures for decades to treat illnesses. These medicinal plants have been found to contain various phytochemical compounds that can help to cure mild to severe illnesses. The inadequacies of conventional medicines and their unusual side effects sparked a determined search for alternative natural therapeutic agents. Another reason for this hunt could be the availability and fewer side effects of natural products. T. arjuna is widely used in traditional medicine to alleviate various diseases like relieving pain, ameliorating diabetes, mitigating inflammation, and back-pedaling of depression. In this study, the ethanolic extract of T. arjuna possesses a promising effect on the animal model (p < 0.05/p < 0.01) as an antihyperglycemic, analgesic, anti-inflammatory, and antidepressant agent, but in a dose-dependent manner. The lower dose of T. arjuna was found to be capable of reversing the disturbed physiological state at a significant level (p < 0.05). However, a higher dose of T. arjuna exerts better therapeutic effects for those diseases. This animal study aims to evaluate the anti-diabetic, anti-depressant, and anti-inflammatory properties of T. arjuna compared to conventional marketed drugs. We will perform an in-silico study for active constituents of T. arjuna against their proposed targets and look for the molecular cascade on their claimed pharmacological properties. This study shows that different doses of T. arjuna bark extracts give similar therapeutic responses compared with established marketed drugs in managing hyperglycemia, stress-induced depression, and inflammation. Besides, our docking study reveals that flavonoids and triterpenoid active constituents of T. arjuna play an important role in its usefulness. This study, therefore, scientifically confirmed the traditional use of this medicinal plant in the management of several diseased conditions.
format	article
author	Md. Rafat Tahsin Arifa Sultana Muhammad Shah Mohtasim Khan Ishrat Jahan Sabiha Rahman Mim Tanzia Islam Tithi Mokaddas Flora Ananta Sadia Afrin Mehnaz Ali M. Sajjad Hussain Jakir Ahmed Chowdhury Shaila Kabir Abu Asad Chowdhury Md. Shah Amran Fahima Aktar
author_facet	Md. Rafat Tahsin Arifa Sultana Muhammad Shah Mohtasim Khan Ishrat Jahan Sabiha Rahman Mim Tanzia Islam Tithi Mokaddas Flora Ananta Sadia Afrin Mehnaz Ali M. Sajjad Hussain Jakir Ahmed Chowdhury Shaila Kabir Abu Asad Chowdhury Md. Shah Amran Fahima Aktar
author_sort	Md. Rafat Tahsin
title	An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach
title_short	An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach
title_full	An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach
title_fullStr	An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach
title_full_unstemmed	An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach
title_sort	evaluation of pharmacological healing potentialities of terminalia arjuna against several ailments on experimental rat models with an in-silico approach
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d547bb7ba18446fabccb061ca0819a82
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An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach

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