Focus on the spectra that matter by clustering of quantification data in shotgun proteomics

Matching mass spectra to peptide sequences is the usual first step in proteomics data analysis, often followed by peptide quantification. Here, the authors show that clustering and quantifying mass spectral features prior to peptide identification can increase the sensitivity of label-free quantitat...

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Autores principales:	Matthew The, Lukas Käll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d548d1a5fa3448b9ab767c181296adad
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spelling	oai:doaj.org-article:d548d1a5fa3448b9ab767c181296adad2021-12-02T17:14:28ZFocus on the spectra that matter by clustering of quantification data in shotgun proteomics10.1038/s41467-020-17037-32041-1723https://doaj.org/article/d548d1a5fa3448b9ab767c181296adad2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17037-3https://doaj.org/toc/2041-1723Matching mass spectra to peptide sequences is the usual first step in proteomics data analysis, often followed by peptide quantification. Here, the authors show that clustering and quantifying mass spectral features prior to peptide identification can increase the sensitivity of label-free quantitative proteomics.Matthew TheLukas KällNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew The Lukas Käll Focus on the spectra that matter by clustering of quantification data in shotgun proteomics
description	Matching mass spectra to peptide sequences is the usual first step in proteomics data analysis, often followed by peptide quantification. Here, the authors show that clustering and quantifying mass spectral features prior to peptide identification can increase the sensitivity of label-free quantitative proteomics.
format	article
author	Matthew The Lukas Käll
author_facet	Matthew The Lukas Käll
author_sort	Matthew The
title	Focus on the spectra that matter by clustering of quantification data in shotgun proteomics
title_short	Focus on the spectra that matter by clustering of quantification data in shotgun proteomics
title_full	Focus on the spectra that matter by clustering of quantification data in shotgun proteomics
title_fullStr	Focus on the spectra that matter by clustering of quantification data in shotgun proteomics
title_full_unstemmed	Focus on the spectra that matter by clustering of quantification data in shotgun proteomics
title_sort	focus on the spectra that matter by clustering of quantification data in shotgun proteomics
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d548d1a5fa3448b9ab767c181296adad
work_keys_str_mv	AT matthewthe focusonthespectrathatmatterbyclusteringofquantificationdatainshotgunproteomics AT lukaskall focusonthespectrathatmatterbyclusteringofquantificationdatainshotgunproteomics
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Focus on the spectra that matter by clustering of quantification data in shotgun proteomics

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