Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus

Cytokines such as TNF and IFN-γ are important for immunity against hepatitis B virus (HBV). Here the authors show that interleukin-32 gamma (IL-32γ) acts downstream of TNF and IFN-γ as an intracellular effector, and that IL-32γ negatively regulates host factors contributing to HBV transcription to p...

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Autores principales:	Doo Hyun Kim, Eun-Sook Park, Ah Ram Lee, Soree Park, Yong Kwang Park, Sung Hyun Ahn, Hong Seok Kang, Ju Hee Won, Yea Na Ha, ByeongJune Jae, Dong-Sik Kim, Woo-Chang Chung, Moon Jung Song, Kee-Hwan Kim, Seung Hwa Park, Soo-Hyun Kim, Kyun-Hwan Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d549107cfed945eba4347f9bdaa68cbe
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spelling	oai:doaj.org-article:d549107cfed945eba4347f9bdaa68cbe2021-12-02T16:50:05ZIntracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus10.1038/s41467-018-05782-52041-1723https://doaj.org/article/d549107cfed945eba4347f9bdaa68cbe2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05782-5https://doaj.org/toc/2041-1723Cytokines such as TNF and IFN-γ are important for immunity against hepatitis B virus (HBV). Here the authors show that interleukin-32 gamma (IL-32γ) acts downstream of TNF and IFN-γ as an intracellular effector, and that IL-32γ negatively regulates host factors contributing to HBV transcription to promote HBV clearance.Doo Hyun KimEun-Sook ParkAh Ram LeeSoree ParkYong Kwang ParkSung Hyun AhnHong Seok KangJu Hee WonYea Na HaByeongJune JaeDong-Sik KimWoo-Chang ChungMoon Jung SongKee-Hwan KimSeung Hwa ParkSoo-Hyun KimKyun-Hwan KimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Doo Hyun Kim Eun-Sook Park Ah Ram Lee Soree Park Yong Kwang Park Sung Hyun Ahn Hong Seok Kang Ju Hee Won Yea Na Ha ByeongJune Jae Dong-Sik Kim Woo-Chang Chung Moon Jung Song Kee-Hwan Kim Seung Hwa Park Soo-Hyun Kim Kyun-Hwan Kim Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus
description	Cytokines such as TNF and IFN-γ are important for immunity against hepatitis B virus (HBV). Here the authors show that interleukin-32 gamma (IL-32γ) acts downstream of TNF and IFN-γ as an intracellular effector, and that IL-32γ negatively regulates host factors contributing to HBV transcription to promote HBV clearance.
format	article
author	Doo Hyun Kim Eun-Sook Park Ah Ram Lee Soree Park Yong Kwang Park Sung Hyun Ahn Hong Seok Kang Ju Hee Won Yea Na Ha ByeongJune Jae Dong-Sik Kim Woo-Chang Chung Moon Jung Song Kee-Hwan Kim Seung Hwa Park Soo-Hyun Kim Kyun-Hwan Kim
author_facet	Doo Hyun Kim Eun-Sook Park Ah Ram Lee Soree Park Yong Kwang Park Sung Hyun Ahn Hong Seok Kang Ju Hee Won Yea Na Ha ByeongJune Jae Dong-Sik Kim Woo-Chang Chung Moon Jung Song Kee-Hwan Kim Seung Hwa Park Soo-Hyun Kim Kyun-Hwan Kim
author_sort	Doo Hyun Kim
title	Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus
title_short	Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus
title_full	Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus
title_fullStr	Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus
title_full_unstemmed	Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus
title_sort	intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis b virus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d549107cfed945eba4347f9bdaa68cbe
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Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus

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