Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent.

Studies in diverse organisms have revealed a surprising depth to the evolutionary conservation of genetic modules. For example, a systematic analysis of such conserved modules has recently shown that genes in yeast that maintain cell walls have been repurposed in vertebrates to regulate vein and art...

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Autores principales: Hye Ji Cha, Michelle Byrom, Paul E Mead, Andrew D Ellington, John B Wallingford, Edward M Marcotte
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/d54a379b43ab4f1ca5f3ee50970cc441
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