Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

The CENP-A chaperone HJURP associates with Mis18α, Mis18β, and M18BP1 to target centromeres and deposit new CENP-A. Here the authors provide evidence that two repeats in human HJURP previously proposed to be functionally distinct are interchangeable and bind concomitantly to the 4:2:2 Mis18α:Mis18β:...

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Autores principales:	Dongqing Pan, Kai Walstein, Annika Take, David Bier, Nadine Kaiser, Andrea Musacchio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d54c0ddeaf074c26b0658f60a5479d52
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spelling	oai:doaj.org-article:d54c0ddeaf074c26b0658f60a5479d522021-12-02T15:36:01ZMechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing10.1038/s41467-019-12019-62041-1723https://doaj.org/article/d54c0ddeaf074c26b0658f60a5479d522019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12019-6https://doaj.org/toc/2041-1723The CENP-A chaperone HJURP associates with Mis18α, Mis18β, and M18BP1 to target centromeres and deposit new CENP-A. Here the authors provide evidence that two repeats in human HJURP previously proposed to be functionally distinct are interchangeable and bind concomitantly to the 4:2:2 Mis18α:Mis18β:M18BP1 complex without dissociating it.Dongqing PanKai WalsteinAnnika TakeDavid BierNadine KaiserAndrea MusacchioNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dongqing Pan Kai Walstein Annika Take David Bier Nadine Kaiser Andrea Musacchio Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing
description	The CENP-A chaperone HJURP associates with Mis18α, Mis18β, and M18BP1 to target centromeres and deposit new CENP-A. Here the authors provide evidence that two repeats in human HJURP previously proposed to be functionally distinct are interchangeable and bind concomitantly to the 4:2:2 Mis18α:Mis18β:M18BP1 complex without dissociating it.
format	article
author	Dongqing Pan Kai Walstein Annika Take David Bier Nadine Kaiser Andrea Musacchio
author_facet	Dongqing Pan Kai Walstein Annika Take David Bier Nadine Kaiser Andrea Musacchio
author_sort	Dongqing Pan
title	Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing
title_short	Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing
title_full	Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing
title_fullStr	Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing
title_full_unstemmed	Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing
title_sort	mechanism of centromere recruitment of the cenp-a chaperone hjurp and its implications for centromere licensing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d54c0ddeaf074c26b0658f60a5479d52
work_keys_str_mv	AT dongqingpan mechanismofcentromererecruitmentofthecenpachaperonehjurpanditsimplicationsforcentromerelicensing AT kaiwalstein mechanismofcentromererecruitmentofthecenpachaperonehjurpanditsimplicationsforcentromerelicensing AT annikatake mechanismofcentromererecruitmentofthecenpachaperonehjurpanditsimplicationsforcentromerelicensing AT davidbier mechanismofcentromererecruitmentofthecenpachaperonehjurpanditsimplicationsforcentromerelicensing AT nadinekaiser mechanismofcentromererecruitmentofthecenpachaperonehjurpanditsimplicationsforcentromerelicensing AT andreamusacchio mechanismofcentromererecruitmentofthecenpachaperonehjurpanditsimplicationsforcentromerelicensing
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Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

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