Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation

Antifungal resistance due to upregulation of efflux pumps is common in Candida albicans. Here, the authors show that conjugation with mitochondria-targeting triphenylphosphonium cation can enhance or restore the antifungal activity of potential efflux pump substrates.

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Autores principales:	Wenqiang Chang, Jun Liu, Ming Zhang, Hongzhuo Shi, Sha Zheng, Xueyang Jin, Yanhui Gao, Shuqi Wang, Aiguo Ji, Hongxiang Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d54c1f11b84d4e14a62e6ec2e2af4489
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spelling	oai:doaj.org-article:d54c1f11b84d4e14a62e6ec2e2af44892021-12-02T15:34:18ZEfflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation10.1038/s41467-018-07633-92041-1723https://doaj.org/article/d54c1f11b84d4e14a62e6ec2e2af44892018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07633-9https://doaj.org/toc/2041-1723Antifungal resistance due to upregulation of efflux pumps is common in Candida albicans. Here, the authors show that conjugation with mitochondria-targeting triphenylphosphonium cation can enhance or restore the antifungal activity of potential efflux pump substrates.Wenqiang ChangJun LiuMing ZhangHongzhuo ShiSha ZhengXueyang JinYanhui GaoShuqi WangAiguo JiHongxiang LouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenqiang Chang Jun Liu Ming Zhang Hongzhuo Shi Sha Zheng Xueyang Jin Yanhui Gao Shuqi Wang Aiguo Ji Hongxiang Lou Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation
description	Antifungal resistance due to upregulation of efflux pumps is common in Candida albicans. Here, the authors show that conjugation with mitochondria-targeting triphenylphosphonium cation can enhance or restore the antifungal activity of potential efflux pump substrates.
format	article
author	Wenqiang Chang Jun Liu Ming Zhang Hongzhuo Shi Sha Zheng Xueyang Jin Yanhui Gao Shuqi Wang Aiguo Ji Hongxiang Lou
author_facet	Wenqiang Chang Jun Liu Ming Zhang Hongzhuo Shi Sha Zheng Xueyang Jin Yanhui Gao Shuqi Wang Aiguo Ji Hongxiang Lou
author_sort	Wenqiang Chang
title	Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation
title_short	Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation
title_full	Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation
title_fullStr	Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation
title_full_unstemmed	Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation
title_sort	efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d54c1f11b84d4e14a62e6ec2e2af4489
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Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation

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