Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation

Antifungal resistance due to upregulation of efflux pumps is common in Candida albicans. Here, the authors show that conjugation with mitochondria-targeting triphenylphosphonium cation can enhance or restore the antifungal activity of potential efflux pump substrates.

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Autores principales: Wenqiang Chang, Jun Liu, Ming Zhang, Hongzhuo Shi, Sha Zheng, Xueyang Jin, Yanhui Gao, Shuqi Wang, Aiguo Ji, Hongxiang Lou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d54c1f11b84d4e14a62e6ec2e2af4489
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