A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans.
The APOBEC3 deaminases are potent inhibitors of virus replication and barriers to cross-species transmission. For simian immunodeficiency virus (SIV) to transmit to a new primate host, as happened multiple times to seed the ongoing HIV-1 epidemic, the viral infectivity factor (Vif) must be capable o...
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Public Library of Science (PLoS)
2020
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oai:doaj.org-article:d550843508e54cdeb238ee8a7ee1d1a42021-12-02T20:00:18ZA role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans.1553-73661553-737410.1371/journal.ppat.1008812https://doaj.org/article/d550843508e54cdeb238ee8a7ee1d1a42020-09-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1008812https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The APOBEC3 deaminases are potent inhibitors of virus replication and barriers to cross-species transmission. For simian immunodeficiency virus (SIV) to transmit to a new primate host, as happened multiple times to seed the ongoing HIV-1 epidemic, the viral infectivity factor (Vif) must be capable of neutralizing the APOBEC3 enzymes of the new host. Although much is known about current interactions of HIV-1 Vif and human APOBEC3s, the evolutionary changes in SIV Vif required for transmission from chimpanzees to gorillas and ultimately to humans are poorly understood. Here, we demonstrate that gorilla APOBEC3G is a factor with the potential to hamper SIV transmission from chimpanzees to gorillas. Gain-of-function experiments using SIVcpzPtt Vif revealed that this barrier could be overcome by a single Vif acidic amino acid substitution (M16E). Moreover, degradation of gorilla APOBEC3F is induced by Vif through a mechanism that is distinct from that of human APOBEC3F. Thus, our findings identify virus adaptations in gorillas that preceded and may have facilitated transmission to humans.Yusuke NakanoKeisuke YamamotoMahoko Takahashi UedaAndrew SoperYoriyuki KonnoIzumi KimuraKeiya UriuRyuichi KumataHirofumi AsoNaoko MisawaShumpei NagaokaSoma ShimizuKeito MitsumuneYusuke KosugiGuillermo Juarez-FernandezJumpei ItoSo NakagawaTerumasa IkedaYoshio KoyanagiReuben S HarrisKei SatoPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 16, Iss 9, p e1008812 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Yusuke Nakano Keisuke Yamamoto Mahoko Takahashi Ueda Andrew Soper Yoriyuki Konno Izumi Kimura Keiya Uriu Ryuichi Kumata Hirofumi Aso Naoko Misawa Shumpei Nagaoka Soma Shimizu Keito Mitsumune Yusuke Kosugi Guillermo Juarez-Fernandez Jumpei Ito So Nakagawa Terumasa Ikeda Yoshio Koyanagi Reuben S Harris Kei Sato A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans. |
| description |
The APOBEC3 deaminases are potent inhibitors of virus replication and barriers to cross-species transmission. For simian immunodeficiency virus (SIV) to transmit to a new primate host, as happened multiple times to seed the ongoing HIV-1 epidemic, the viral infectivity factor (Vif) must be capable of neutralizing the APOBEC3 enzymes of the new host. Although much is known about current interactions of HIV-1 Vif and human APOBEC3s, the evolutionary changes in SIV Vif required for transmission from chimpanzees to gorillas and ultimately to humans are poorly understood. Here, we demonstrate that gorilla APOBEC3G is a factor with the potential to hamper SIV transmission from chimpanzees to gorillas. Gain-of-function experiments using SIVcpzPtt Vif revealed that this barrier could be overcome by a single Vif acidic amino acid substitution (M16E). Moreover, degradation of gorilla APOBEC3F is induced by Vif through a mechanism that is distinct from that of human APOBEC3F. Thus, our findings identify virus adaptations in gorillas that preceded and may have facilitated transmission to humans. |
| format |
article |
| author |
Yusuke Nakano Keisuke Yamamoto Mahoko Takahashi Ueda Andrew Soper Yoriyuki Konno Izumi Kimura Keiya Uriu Ryuichi Kumata Hirofumi Aso Naoko Misawa Shumpei Nagaoka Soma Shimizu Keito Mitsumune Yusuke Kosugi Guillermo Juarez-Fernandez Jumpei Ito So Nakagawa Terumasa Ikeda Yoshio Koyanagi Reuben S Harris Kei Sato |
| author_facet |
Yusuke Nakano Keisuke Yamamoto Mahoko Takahashi Ueda Andrew Soper Yoriyuki Konno Izumi Kimura Keiya Uriu Ryuichi Kumata Hirofumi Aso Naoko Misawa Shumpei Nagaoka Soma Shimizu Keito Mitsumune Yusuke Kosugi Guillermo Juarez-Fernandez Jumpei Ito So Nakagawa Terumasa Ikeda Yoshio Koyanagi Reuben S Harris Kei Sato |
| author_sort |
Yusuke Nakano |
| title |
A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans. |
| title_short |
A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans. |
| title_full |
A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans. |
| title_fullStr |
A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans. |
| title_full_unstemmed |
A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans. |
| title_sort |
role for gorilla apobec3g in shaping lentivirus evolution including transmission to humans. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2020 |
| url |
https://doaj.org/article/d550843508e54cdeb238ee8a7ee1d1a4 |
| work_keys_str_mv |
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