Fan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment

Jianbo Hu,1,2,* Jianbo Lai,1,2,* Hanzhi Zheng,3 Shaohua Hu,1,2 Yi Xu1,2 1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou, China; 3Department of...

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Autores principales:	Hu JB, Lai JB, Zheng HZ, Hu SH, Xu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	trazodone sertraline depression mania Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d5512515d8f241b9880bf3be1b56f7ac
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spelling	oai:doaj.org-article:d5512515d8f241b9880bf3be1b56f7ac2021-12-02T00:38:41ZFan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment1178-2021https://doaj.org/article/d5512515d8f241b9880bf3be1b56f7ac2017-08-01T00:00:00Zhttps://www.dovepress.com/fan-the-flame-trazodone-induced-mania-in-a-unipolar-depressed-patient--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jianbo Hu,1,2,* Jianbo Lai,1,2,* Hanzhi Zheng,3 Shaohua Hu,1,2 Yi Xu1,2 1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou, China; 3Department of Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, China *These authors contributed equally to this work Abstract: Depressed patients often complain of sleep disturbance. Routine antidepressive strategies sometimes fail to deal with this intractable issue. Indeed, the supplementation of sleep promoting antidepressants (eg, trazodone, mirtazapine, and agomelatine) is prevalent in clinical practice. However, the combination of different antidepressants may increase the affective lability. Herein, we document a patient with unipolar depression who was compliant with sertraline treatment and who dramatically switched to mania after adding trazodone as a sleeping aid. This case extended our understanding of the potential manic-switching risk when trazodone is used to promote sleep. Keywords: trazodone, sertraline, depression, maniaHu JBLai JBZheng HZHu SHXu YDove Medical PressarticletrazodonesertralinedepressionmaniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2251-2254 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	trazodone sertraline depression mania Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	trazodone sertraline depression mania Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hu JB Lai JB Zheng HZ Hu SH Xu Y Fan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment
description	Jianbo Hu,1,2,* Jianbo Lai,1,2,* Hanzhi Zheng,3 Shaohua Hu,1,2 Yi Xu1,2 1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou, China; 3Department of Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, China *These authors contributed equally to this work Abstract: Depressed patients often complain of sleep disturbance. Routine antidepressive strategies sometimes fail to deal with this intractable issue. Indeed, the supplementation of sleep promoting antidepressants (eg, trazodone, mirtazapine, and agomelatine) is prevalent in clinical practice. However, the combination of different antidepressants may increase the affective lability. Herein, we document a patient with unipolar depression who was compliant with sertraline treatment and who dramatically switched to mania after adding trazodone as a sleeping aid. This case extended our understanding of the potential manic-switching risk when trazodone is used to promote sleep. Keywords: trazodone, sertraline, depression, mania
format	article
author	Hu JB Lai JB Zheng HZ Hu SH Xu Y
author_facet	Hu JB Lai JB Zheng HZ Hu SH Xu Y
author_sort	Hu JB
title	Fan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment
title_short	Fan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment
title_full	Fan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment
title_fullStr	Fan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment
title_full_unstemmed	Fan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment
title_sort	fan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d5512515d8f241b9880bf3be1b56f7ac
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Fan the flame: trazodone-induced mania in a unipolar depressed patient with stable sertraline treatment

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